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Association between serum estradiol level on the human chorionic gonadotrophin administration day and clinical outcome

Chinese medical journal, 2019-05, Vol.132 (10), p.1194-1201 [Peer Reviewed Journal]

Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. This work is published under http://creativecommons.org/licenses/by-nc-nd/4.0 (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;Copyright © Wanfang Data Co. Ltd. All Rights Reserved. ;Copyright © 2019 The Chinese Medical Association, produced by Wolters Kluwer, Inc. under the CC-BY-NC-ND license. 2019 ;ISSN: 0366-6999 ;EISSN: 2542-5641 ;DOI: 10.1097/CM9.0000000000000251 ;PMID: 30973445

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  • Title:
    Association between serum estradiol level on the human chorionic gonadotrophin administration day and clinical outcome
  • Author: Li, Xin ; Zeng, Cheng ; Shang, Jing ; Wang, Sheng ; Gao, Xue-Lian ; Xue, Qing
  • Subjects: Age ; Birth weight ; Births ; Blood pressure ; Chorionic Gonadotropin - administration & dosage ; Chorionic Gonadotropin - therapeutic use ; Clinical outcomes ; Drug dosages ; Embryos ; Estradiol - blood ; Female ; Fertilization in Vitro ; Humans ; In vitro fertilization ; Infant, Low Birth Weight ; Infertility ; Oocyte Retrieval ; Oocytes - drug effects ; Original ; Ovaries ; Ovulation Induction - methods ; Patients ; Pregnancy ; Pregnancy Rate ; Regression analysis ; Reproductive technologies ; Retrospective Studies ; Statistical analysis ; Ultrasonic imaging ; Vagina
  • Is Part Of: Chinese medical journal, 2019-05, Vol.132 (10), p.1194-1201
  • Description: Estradiol, as an important hormone in follicular development and endometrial receptivity, is closely related to clinical outcomes of fresh in vitro fertilization embryo transfer (IVF-ET) cycles. The aim of this retrospective study was to evaluate the association between elevated serum estradiol (E2) levels on the day of human chorionic gonadotrophin (hCG) administration and IVF-ET pregnancy and birth outcomes. A total of 1771 infertile patients with their first fresh IVF-ET cycles were analyzed retrospectively between January 2011 and January 2016 in Peking University First Hospital. Patients were categorized by serum E2 levels on the day of hCG administration into six groups: group 1 (serum E2 levels ≤ 1000 pg/mL, n = 205), group 2 (serum E2 levels 1001-2000 pg/mL, n = 457), group 3 (serum E2 levels 2001-3000 pg/mL, n = 425), group 4 (serum E2 levels 3001-4000 pg/mL, n = 310), group 5 (serum E2 levels 4001-5000 pg/mL, n = 237), and group 6 (serum E2 levels > 5000 pg/mL, n = 137). The retrieved oocyte and MII oocyte numbers and implantation and clinical pregnancy rates of the groups were compared as the first objective of the study. For the 360 women with singleton births among all patients, the area under the corresponding receiver operating characteristic curve (ROC curve) was calculated to assess the predictive value of the E2 change for the probability of low birth weight (LBW) infants as the second objective. The retrieved oocyte and MII oocyte numbers and implantation and clinical pregnancy rates gradually increased from groups 1 to 5 but decreased in group 6. The parameters of group 1 were statistically worse than those of the other groups, from group 2 to group 6 (the number of retrieved oocytes, t = 13.096, t = 23.307, t = 23.086, t = 26.376, t = 19.636, P < 0.003; the number of retrieved MII oocytes, t = 10.856, t = 20.868, t = 21.874, t = 23.374, t = 19.092, P < 0.003; the implantation rate, χ = 12.179, χ = 22.239, χ = 23.993, χ = 23.344, χ = 16.758, P < 0.003; the clinical pregnancy rate, χ = 16.415, χ = 28.074, χ = 35.387, χ = 37.025, χ = 24.590, P < 0.003). ROC analysis revealed that when a serum peak E2 of 3148 pg/mL was used to predict LBW. The results indicate that serum E2 levels have a concentration-dependent effect on clinical outcomes. The optimal range of the E2 level during a fresh IVF-ET cycle is 1000 to 3148 pg/mL.
  • Publisher: China: Lippincott Williams & Wilkins Ovid Technologies
  • Language: English
  • Identifier: ISSN: 0366-6999
    EISSN: 2542-5641
    DOI: 10.1097/CM9.0000000000000251
    PMID: 30973445
  • Source: Journals@Ovid Open Access Journal Collection Rolling
    DOAJ Directory of Open Access Journals
    GFMER Free Medical Journals
    MEDLINE
    PubMed Central
    ProQuest Central
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