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Three-dimensional cell culture: a breakthrough in vivo

International Journal of Molecular Sciences, 2015-03, Vol.16 (3), p.5517-5527 [Peer Reviewed Journal]

Copyright MDPI AG 2015 ;2015 by the authors; licensee MDPI, Basel, Switzerland. 2015 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms16035517 ;PMID: 25768338

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  • Title:
    Three-dimensional cell culture: a breakthrough in vivo
  • Author: Antoni, Delphine ; Burckel, Hélène ; Josset, Elodie ; Noel, Georges
  • Subjects: Animals ; Cell culture ; Humans ; in vivo ; Primary Cell Culture - instrumentation ; Primary Cell Culture - methods ; Review ; Spheroids, Cellular - cytology ; Spheroids, Cellular - physiology ; Three dimensional imaging ; three-dimensional cell culture ; Tissue Engineering - methods
  • Is Part Of: International Journal of Molecular Sciences, 2015-03, Vol.16 (3), p.5517-5527
  • Description: Cell culture is an important tool for biological research. Two-dimensional cell culture has been used for some time now, but growing cells in flat layers on plastic surfaces does not accurately model the in vivo state. As compared to the two-dimensional case, the three-dimensional (3D) cell culture allows biological cells to grow or interact with their surroundings in all three dimensions thanks to an artificial environment. Cells grown in a 3D model have proven to be more physiologically relevant and showed improvements in several studies of biological mechanisms like: cell number monitoring, viability, morphology, proliferation, differentiation, response to stimuli, migration and invasion of tumor cells into surrounding tissues, angiogenesis stimulation and immune system evasion, drug metabolism, gene expression and protein synthesis, general cell function and in vivo relevance. 3D culture models succeed thanks to technological advances, including materials science, cell biology and bioreactor design.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 1422-0067
    ISSN: 1661-6596
    EISSN: 1422-0067
    DOI: 10.3390/ijms16035517
    PMID: 25768338
  • Source: MEDLINE
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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