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Value of CRP/albumin ratio as a prognostic marker of acute pancreatitis: a retrospective study

Revista española de enfermedades digestivas, 2023-12, Vol.115 (12), p.708 [Peer Reviewed Journal]

COPYRIGHT 2023 Sociedad Espanola de Patologia Digestivas ;ISSN: 1130-0108 ;DOI: 10.17235/reed2023.9345/2022

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  • Title:
    Value of CRP/albumin ratio as a prognostic marker of acute pancreatitis: a retrospective study
  • Author: Pinerua-Gonsalvez, Jean Felix ; Ruiz-Rebollo, Marfa Lourdes ; Zambrano-Infantino, Rosanna del Carmen ; Rizzo-Rodrfguez, Marfa Antonella ; Fernandez-Salazar, Luis
  • Subjects: Albumin ; Blood ; C-reactive protein ; Health aspects ; Medical examination ; Medical research ; Medicine, Experimental ; Pancreatitis ; Prognosis
  • Is Part Of: Revista española de enfermedades digestivas, 2023-12, Vol.115 (12), p.708
  • Description: The present study investigated the potential of C-reactive protein (CRP) to albumin ratio in predicting the severity of acute pancreatitis. Data from 722 patients diagnosed with acute pancreatitis were analyzed, revealing a significant association between the CRP/albumin ratio and severe cases of the condition. Each 10-unit increase in the ratio was found to be associated with a 20 % higher likelihood of developing severe pancreatitis. A comparison was made between the performance of the CRP/albumin ratio and the commonly used Ranson criteria scoring system, demonstrating that the ratio had a higher predictive value for severe acute pancreatitis. An optimal cut-off value of 7.51 was identified for the CRP/albumin ratio in identifying severe acute pancreatitis. At this threshold, the test showed a sensitivity of 63.4 % and specif icity of 65.6 %. Despite limitations in terms of sensitivity and specif icity, the CRP/albumin ratio could serve as a supplementary tool alongside existing scoring systems in the initial assessment of acute pancreatitis. Obtained easily through a blood test, the ratio provides additional prognostic information, assisting clinicians in evaluating the severity of the condition and making informed treatment decisions. Further research is required to validate these findings and evaluate the clinical utility of the CRP/albumin ratio in managing acute pancreatitis. Introduction: the C-reactive protein (CRP) to albumin ratio is an inflammatory marker that has shown promise in the prognosis of critically ill patients. This study is aimed to assess the value of CRP/albumin ratio to predict severity in acute pancreatitis. Methods: a retrospective study was performed using a prospectively collected database of patients diagnosed with AP admitted to the Department of Gastroenterology between March 2014 and December 2021. Results: among 722 patients included in the study, 78.67 % had mild, 15.65 % had moderately severe, and 5.67 % had severe acute pancreatitis. The CRP/albumin ratio was significantly associated with severe AP (OR 1.02; 95 % CI: 1.01-1.03; p < 0.001), and each ten-unit increase in the ratio was associated with a 20 % increased likelihood of severe acute pancreatitis. The area under the ROC curve (AUC) value of the CRP/albumin ratio in severe acute pancreatitis was 0.68 (95 % CI: 0.58-0.77), which was higher than that of the Ranson criteria (0.62). The optimal cut-off value for predicting severe acute pancreatitis was 7.51, with a sensitivity of 63.4 % and specificity of 65.6 %. Conclusions: despite its low sensitivity and specificity, the CRP/albumin ratio could be used as a complementary marker to the current scoring systems for the initial assessment of acute pancreatitis prognosis. It is easily obtainable and can provide additional prognostic information to clinicians. Keywords: Acute pancreatitis. C-reactive protein. Serum albumin. Organ failure. Biomarkers.
  • Publisher: Sociedad Espanola de Patologia Digestivas
  • Language: Spanish
  • Identifier: ISSN: 1130-0108
    DOI: 10.17235/reed2023.9345/2022
  • Source: DOAJ Directory of Open Access Journals
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