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Best PEEP trials are dependent on tidal volume

Critical care (London, England), 2018-05, Vol.22 (1), p.115-115, Article 115 [Peer Reviewed Journal]

COPYRIGHT 2018 BioMed Central Ltd. ;The Author(s). 2018 ;ISSN: 1364-8535 ;EISSN: 1466-609X ;DOI: 10.1186/s13054-018-2047-4 ;PMID: 29720277

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Title:
Best PEEP trials are dependent on tidal volume
Author: McKown, Andrew C ; Semler, Matthew W ; Rice, Todd W
Subjects: Acute stress disorder ; Adult respiratory distress syndrome ; Care and treatment ; Control ; Humans ; Letter ; Positive-Pressure Respiration - methods ; Positive-Pressure Respiration - statistics & numerical data ; Respiration, Artificial - methods ; Respiration, Artificial - standards ; Respiration, Artificial - trends ; Respiratory Distress Syndrome - therapy ; Tidal Volume - physiology
Is Part Of: Critical care (London, England), 2018-05, Vol.22 (1), p.115-115, Article 115
Description: Determining the optimal positive end-expiratory pressure (PEEP) in patients with acute respiratory distress syndrome remains an area of active investigation. Most trials individualizing PEEP optimize one physiologic parameter (e.g., driving pressure) by titrating PEEP while holding other ventilator settings constant. Optimal PEEP, however, may depend on the tidal volume, and changing the tidal volume with which a best PEEP trial is performed may lead to different best PEEP settings in the same patient. ClinicalTrials.gov, NCT02871102. Registered on 12 August 2016.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1364-8535
EISSN: 1466-609X
DOI: 10.1186/s13054-018-2047-4
PMID: 29720277
Source: MEDLINE
PubMed Central
Alma/SFX Local Collection
Springer Nature OA/Free Journals
ProQuest Central
DOAJ Directory of Open Access Journals

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Best PEEP trials are dependent on tidal volume

COPYRIGHT 2018 BioMed Central Ltd. ;The Author(s). 2018 ;ISSN: 1364-8535 ;EISSN: 1466-609X ;DOI: 10.1186/s13054-018-2047-4 ;PMID: 29720277

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