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Hyaluronic acid stimulation of stem cells for cardiac repair: a cell-free strategy for myocardial infarct

Journal of nanobiotechnology, 2024-04, Vol.22 (1), p.149-149 [Peer Reviewed Journal]

2024. The Author(s). ;COPYRIGHT 2024 BioMed Central Ltd. ;2024. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2024 ;ISSN: 1477-3155 ;EISSN: 1477-3155 ;DOI: 10.1186/s12951-024-02410-x ;PMID: 38570846

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Title:
Hyaluronic acid stimulation of stem cells for cardiac repair: a cell-free strategy for myocardial infarct
Author: Jeong, Seon-Yeong ; Park, Bong-Woo ; Kim, Jimin ; Lee, Seulki ; You, Haedeun ; Lee, Joohyun ; Lee, Susie ; Park, Jae-Hyun ; Kim, Jinju ; Sim, Woosup ; Ban, Kiwon ; Park, Joonghoon ; Park, Hun-Jun ; Kim, Soo
Subjects: Angiogenesis ; Antibodies ; Blood vessels ; Cardiac function ; Cardiomyocytes ; Cardiovascular diseases ; Care and treatment ; Cell cycle ; Cell organelles ; Cytokines ; Echocardiography ; Endothelial cells ; Endothelial Cells - metabolism ; Extracellular matrix ; Extracellular vesicles ; Fibroblasts ; Fibrosis ; Health aspects ; Heart ; Heart attack ; Heart diseases ; Humans ; Hyaluronic acid ; Hyaluronic Acid - pharmacology ; Immunity ; Induced Mesenchymal stem cells ; Inflammasomes ; Inflammation ; Invoices ; Ischemia ; Laboratories ; Localization ; Macrophages ; Medical research ; Medicine, Experimental ; Mesenchymal stem cells ; Mesenchymal Stem Cells - metabolism ; Myocardial infarction ; Myocardial Infarction - pathology ; Myocardial Infarction - therapy ; Myocardium ; Myocytes, Cardiac - metabolism ; Nanoparticles ; Oxidative stress ; Oxygen ; Proteins ; Proteomics ; Reactive oxygen species ; Reactive Oxygen Species - metabolism ; Regenerative medicine ; Smad2 protein ; Stem cells ; Survival ; Tissue engineering ; Transforming growth factor-b1 ; Transmission electron microscopy
Is Part Of: Journal of nanobiotechnology, 2024-04, Vol.22 (1), p.149-149
Description: Myocardial infarction (MI), a representative form of ischemic heart disease, remains a huge burden worldwide. This study aimed to explore whether extracellular vesicles (EVs) secreted from hyaluronic acid (HA)-primed induced mesenchymal stem cells (HA-iMSC-EVs) could enhance the cardiac repair after MI. HA-iMSC-EVs showed typical characteristics for EVs such as morphology, size, and marker proteins expression. Compared with iMSC-EVs, HA-iMSC-EVs showed enhanced tube formation and survival against oxidative stress in endothelial cells, while reduced reactive oxygen species (ROS) generation in cardiomyocytes. In THP-1 macrophages, both types of EVs markedly reduced the expression of pro-inflammatory signaling players, whereas HA-iMSC-EVs were more potent in augmenting anti-inflammatory markers. A significant decrease of inflammasome proteins was observed in HA-iMSC-EV-treated THP-1. Further, phospho-SMAD2 as well as fibrosis markers in TGF-β1-stimulated cardiomyocytes were reduced in HA-iMSC-EVs treatment. Proteomic data showed that HA-iMSC-EVs were enriched with multiple pathways including immunity, extracellular matrix organization, angiogenesis, and cell cycle. The localization of HA-iMSC-EVs in myocardium was confirmed after delivery by either intravenous or intramyocardial route, with the latter increased intensity. Echocardiography revealed that intramyocardial HA-iMSC-EVs injections improved cardiac function and reduced adverse cardiac remodeling and necrotic size in MI heart. Histologically, MI hearts receiving HA-iMSC-EVs had increased capillary density and viable myocardium, while showed reduced fibrosis. Our results suggest that HA-iMSC-EVs improve cardiac function by augmenting vessel growth, while reducing ROS generation, inflammation, and fibrosis in MI heart.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1477-3155
EISSN: 1477-3155
DOI: 10.1186/s12951-024-02410-x
PMID: 38570846
Source: SpringerOpen
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
Directory of Open Access Journals
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central

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Hyaluronic acid stimulation of stem cells for cardiac repair: a cell-free strategy for myocardial infarct

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