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Inflammatory markers and onset of cardiovascular events: Results from the health ABC study

Circulation (New York, N.Y.), 2003-11, Vol.108 (19), p.2317-2322 [Peer Reviewed Journal]

2004 INIST-CNRS ;Copyright American Heart Association, Inc. Nov 11 2003 ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/01.CIR.0000097109.90783.FC ;PMID: 14568895 ;CODEN: CIRCAZ

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Title:
Inflammatory markers and onset of cardiovascular events: Results from the health ABC study
Author: CESARI, Matteo ; PENNINX, Brenda W. J. H ; PAHOR, Marco ; NEWMAN, Anne B ; KRITCHEVSKY, Stephen B ; NICKLAS, Barbara J ; SUTTON-TYRRELL, Kim ; RUBIN, Susan M ; JINGZHONG DING ; SIMONSICK, Eleanor M ; HARRIS, Tamara B
Subjects: Aged ; Biological and medical sciences ; Biomarkers ; Blood and lymphatic vessels ; C-Reactive Protein - analysis ; Cardiology. Vascular system ; Cardiovascular Diseases - blood ; Cardiovascular Diseases - epidemiology ; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous ; Female ; Follow-Up Studies ; Humans ; Incidence ; Inflammation - blood ; Interleukin-6 - blood ; Male ; Medical sciences ; Predictive Value of Tests ; Prospective Studies ; Risk Factors ; Tumor Necrosis Factor-alpha - analysis
Is Part Of: Circulation (New York, N.Y.), 2003-11, Vol.108 (19), p.2317-2322
Description: Inflammation plays an important role in cardiovascular disease. The aim of this study is to investigate the predictive value of several inflammatory markers on the incidence of cardiovascular events in well-functioning older persons. The subjects were 2225 participants 70 to 79 years old, without baseline cardiovascular disease, who were enrolled in the Health, Aging, and Body Composition study. Incident coronary heart disease (CHD), stroke, and congestive heart failure (CHF) events were detected during an average follow-up of 3.6 years. Blood levels of interleukin-6 (IL-6), C-reactive protein (CRP), and tumor necrosis factor-alpha (TNF-alpha) were assessed. After adjustment for potential confounders, IL-6 was significantly associated with all outcomes (CHD events, per IL-6 SD increase: RR, 1.27; 95% CI, 1.10 to 1.48; stroke events, per IL-6 SD increase: RR, 1.45; 95% CI, 1.12 to 1.86; CHF events, per IL-6 SD increase: RR, 1.72; 95% CI, 1.40 to 2.12). TNF-alpha showed significant associations with CHD (per TNF-alpha SD increase: RR, 1.22; 95% CI, 1.04 to 1.43) and CHF (per TNF-alpha SD increase: RR, 1.59; 95% CI, 1.30 to 1.95) events. CRP was significantly associated with CHF events (per CRP SD increase: RR, 1.48; 95% CI, 1.23 to 1.78). A composite summary indicator of inflammation showed a strong association with incident cardiovascular events, with an especially high risk if all 3 inflammatory markers were in the highest tertile. Findings suggest that inflammatory markers are independent predictors of cardiovascular events in older persons.
Publisher: Hagerstown, MD: Lippincott Williams & Wilkins
Language: English
Identifier: ISSN: 0009-7322
EISSN: 1524-4539
DOI: 10.1161/01.CIR.0000097109.90783.FC
PMID: 14568895
CODEN: CIRCAZ
Source: GFMER Free Medical Journals
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Inflammatory markers and onset of cardiovascular events: Results from the health ABC study

2004 INIST-CNRS ;Copyright American Heart Association, Inc. Nov 11 2003 ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/01.CIR.0000097109.90783.FC ;PMID: 14568895 ;CODEN: CIRCAZ

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