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Oxidative Indices Correlate with Dyslipidemia and Pro-Inflammatory Cytokine Levels in Fluoride-Exposed Rats

Arhiv za higijenu rada i toksikologiju, 2013-12, Vol.64 (4), p.521-529 [Peer Reviewed Journal]

ISSN: 0004-1254 ;EISSN: 1848-6312 ;DOI: 10.2478/10004-1254-64-2013-2351 ;PMID: 24384758

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  • Title:
    Oxidative Indices Correlate with Dyslipidemia and Pro-Inflammatory Cytokine Levels in Fluoride-Exposed Rats
  • Author: Afolabi, Olusegun Kayode ; Oyewo, Emmanuel Bukoye ; Adekunle, Adeniran Sanmi ; Adedosu, Olaniyi Tope ; Adedeji, Adebayo Lawrence
  • Subjects: Administration, Oral ; Animals ; Aryldialkylphosphatase - blood ; bolesti srca i krvožilja ; Cardiovascular Diseases - chemically induced ; Cardiovascular Diseases - metabolism ; cardiovascular disorders ; Cytokines - drug effects ; Cytokines - metabolism ; Dyslipidemias - chemically induced ; Dyslipidemias - metabolism ; Fluorides - toxicity ; IL-2 ; IL-6 ; Lipid Metabolism - drug effects ; lipidni hidroperoksid ; Male ; Malondialdehyde - blood ; paraoksonaza ; paraoxonase ; plasma lipid hydroperoxide ; Rats ; TNF-α ; Toxicity Tests, Chronic
  • Is Part Of: Arhiv za higijenu rada i toksikologiju, 2013-12, Vol.64 (4), p.521-529
  • Description: The aim of this study was to establish the effects of fluoride on lipid metabolism and attendant inflammatory response by exposing rats to 50 mg L and 100 mg L of fluoride through drinking water for seven weeks. Both concentrations led to hypercholesterolemia while the 100 mg L concentration induced hypertriglyceridaemia. High density lipoprotein (HDL) cholesterol levels dropped in the exposed rats while interleukin 2 (IL-2) increased more than 1.5-fold (p<0.05) and IL-6 and plasma TNF-α more than 2.5 fold (p<0.05). Fluoride-exposed rats also had significantly higher levels of liver malondialdehyde (MDA) and plasma lipid hydroperoxide (LOOH) but lower plasma paraoxonase (PON1) activity. Oxidative stress indices correlated with pro-inflammatory cytokines and plasma cholesterol. In contrast, proinflammatory cytokines inversely correlated with plasma triglyceride, HDL cholesterol and PON1. Our results suggest that the association between fluoride exposure with cardiovascular diseases may be related to its ability to disturb lipid homeostasis, and trigger pro-inflammatory cytokines and oxidative stress. Svrha je ovog istraživanja bila utvrditi djelovanje fluorida na metabolizam lipida i upalni odgovor tako što smo štakore izložili fluoridu u pitkoj vodi u koncentracijama od 50 mg L i 100 mg L sedam tjedana. Obje su koncentracije dovele do hiperkolesterolemije, a viša je koncentracija inducirala i hipertrigliceridemiju. U odnosu na kontrolnu skupinu, u izloženih su se štakora razine lipoproteina visoke gustoće (HDL-a) smanjile, a interleukin 2 (IL-2) se povećao više od 1,5 put (p<0,05), kao i IL-6 i čimbenik tumorske nekroze alfa (TNF-α) u plazmi, i to više od 2,5 puta (p<0,05). Usto su izloženi štakori iskazali značajno više razine malondialdehida (MDA) u jetrima te lipidnog hidroperoksida (LOOH) u plazmi, odnosno sniženu aktivnost paraoksonaze (PON1) u plazmi. Indikatori oksidacijskog stresa korelirali su s upalnim citokinima i kolesterolom u plazmi, a upalni citokini inverzno su korelirali s trigliceridima, HDL kolesterolom i PON1 u plazmi. Rezultati istraživanja upućuju na to da povezanost između izloženosti fluoridu i bolesti srca i krvožilja možda potječe od toga što fluorid remeti lipidnu homeostazu te pokreće upalne citokine i, posljedično, oksidacijski stres.
  • Publisher: Croatia: Versita
  • Language: English;Croatian
  • Identifier: ISSN: 0004-1254
    EISSN: 1848-6312
    DOI: 10.2478/10004-1254-64-2013-2351
    PMID: 24384758
  • Source: Sciendo (De Gruyter) Open Access Journals
    MEDLINE
    ProQuest Central
    DOAJ Directory of Open Access Journals
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