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The Author(s) 2021 ;2021. The Author(s). ;The Author(s) 2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 0340-7004 ;EISSN: 1432-0851 ;DOI: 10.1007/s00262-021-02872-0 ;PMID: 33576874

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