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Burden of disease and costs associated with type 2 diabetes in emerging and established markets: systematic review analyses

Expert review of pharmacoeconomics & outcomes research, 2021-07, Vol.21 (4), p.785-798 [Peer Reviewed Journal]

2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. 2020 ;ISSN: 1473-7167 ;EISSN: 1744-8379 ;DOI: 10.1080/14737167.2020.1782748

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  • Title:
    Burden of disease and costs associated with type 2 diabetes in emerging and established markets: systematic review analyses
  • Author: Alzaid, Aus ; Ladrón de Guevara, Patricia ; Beillat, Maud ; Lehner Martin, Valérie ; Atanasov, Petar
  • Subjects: Burden of illness ; Cost of illness ; Economic burden ; Emerging market ; Established market ; Systematic literature review ; Type 2 diabetes ; Type 2 diabetes care ; Type 2 diabetes complications ; Type 2 diabetes epidemiology
  • Is Part Of: Expert review of pharmacoeconomics & outcomes research, 2021-07, Vol.21 (4), p.785-798
  • Description: Objectives: To estimate the clinical and economic burden of type 2 diabetes (T2D) in established (EST) and emerging markets (EMG). Methods: Three systematic literature reviews were conducted in MEDLINE and Embase to capture all relevant publications reporting 1) the epidemiology of T2D and complications in T2D and 2) the economic burden of T2D and associated complications. Results: In total, 294 studies were included in this analysis. Evidence indicates a high and increasing overall prevalence of T2D globally, ranging up to 23% in EMG markets and 14% in EST markets. Undiagnosed cases were higher in EMG versus EST markets (up to 67% vs 38%), potentially due to a lack of education and disease awareness in certain regions, that could lead to important clinical and economic consequences. Poor glycemic control was associated with the development of several complications (e.g. retinopathy, cardiovascular diseases and nephropathy) that increase the risk of morbidity and mortality. Direct costs were up to 9-fold higher in patients with vs without T2D-related complications. Conclusions: The burden of T2D, related complications and inherent costs are higher in emerging versus established market countries. This review explores potential strategies to reduce costs and enhance outcomes of T2D treatment in developing countries.
  • Publisher: Taylor & Francis
  • Language: English
  • Identifier: ISSN: 1473-7167
    EISSN: 1744-8379
    DOI: 10.1080/14737167.2020.1782748
  • Source: Taylor & Francis Open Access
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