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N-GLYCOSYLATION OF IMMUNOGLOBULIN G AND TOTAL PLASMA PROTEINS IN CORONARY ARTERY DISEASE

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  • Title:
    N-GLYCOSYLATION OF IMMUNOGLOBULIN G AND TOTAL PLASMA PROTEINS IN CORONARY ARTERY DISEASE
  • Author: RADOVANI, BARBARA
  • Subjects: Biofizika ; Biokemija ; Biologija ; biomarker ; glikozilacija ; imunoglobulin G ; koronarna bolest srca ; Molekularna biologija ; PRIRODNE ZNANOSTI ; proteini plazme ; upala
  • Description: Coronary artery disease (CAD) is the most common cardiovascular disease (CVD), resulting from chronic inflammation of the coronary arteries due to the formation of atherosclerotic plaques, and its presence is a significant marker of adverse cardiovascular (CV) events. Previous research has linked N-glycosylation, a highly regulated posttranslational modification, to the development of atherosclerotic plaques. Therefore, the aim of this work was to determine whether N-glycosylation of total plasma proteins and, in particular, immunoglobulin G (IgG) is associated with CAD. Sex-stratified analysis of N-glycosylation of total plasma proteins and IgG revealed significant changes associated with CAD, with different patterns observed in men and women. Highly branched sialylated plasma N-glycan structures with terminal fucose were positively associated, whereas biantennary sialylated IgG N-glycan structures were negatively associated with CAD. Overall, protein N-glycosylation emerges as a significant factor in CAD, with glycan-based biomarkers showing promise for predicting cardiovascular health. Koronarna bolest srca (KBS) najčešća je kardiovaskularna bolest (KVB), koja nastaje kao posljedica kronične upale koronarnih arterija uslijed stvaranja aterosklerotskih plakova, a njezina je prisutnost značajan biljeg štetnih kardiovaskularnih (KV) događaja. Prethodna su istraživanja povezala N-glikozilaciju, visoko reguliranu posttranslacijsku modifikaciju, s razvojem aterosklerotskih plakova. Stoga je cilj ovog doktorskog rada bio utvrditi je li Nglikom ukupnih proteina plazme, a posebice imunoglobulina G (IgG), povezan s KBS-om. Spolno stratificirana analiza N-glikozilacije ukupnih proteina plazme i IgG otkrila je značajne promjene povezane s KBS-om, s različitim obrascima uočenim u muškaraca i žena. Visoko razgranate sijalizirane N-glikanske strukture proteina plazme s terminalnom fukozom bile su pozitivno povezane, dok su biantenarne sijalizirane IgG N-glikanske strukture bile negativno povezane s KBS-om. Sve u svemu, N-glikozilacija proteina pojavljuje se kao značajan čimbenik u KBS-u, te biljezi temeljeni na glikanima predstavljaju potencijal za predviđanje kardiovaskularnog zdravlja.
  • Publisher: University of Zagreb. Faculty of Science. Department of Biology
  • Creation Date: 2023
  • Language: English
  • Source: DABAR Digital Academic Archives and Repositories
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