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The role of inflammation in diabetic eye disease

Seminars in immunopathology, 2019-07, Vol.41 (4), p.427-445 [Peer Reviewed Journal]

Springer-Verlag GmbH Germany, part of Springer Nature 2019 ;Seminars in Immunopathology is a copyright of Springer, (2019). All Rights Reserved. ;ISSN: 1863-2297 ;EISSN: 1863-2300 ;DOI: 10.1007/s00281-019-00750-7 ;PMID: 31175392

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Title:
The role of inflammation in diabetic eye disease
Author: Mesquida, Marina ; Drawnel, Faye ; Fauser, Sascha
Subjects: Angiopoietin ; Angiopoietin-2 - antagonists & inhibitors ; Angiopoietin-2 - metabolism ; Animals ; Anti-Inflammatory Agents - therapeutic use ; Biomedical and Life Sciences ; Biomedicine ; Blood-Retinal Barrier - metabolism ; Blood-Retinal Barrier - pathology ; Diabetes ; Diabetes mellitus ; Diabetic retinopathy ; Diabetic Retinopathy - drug therapy ; Diabetic Retinopathy - metabolism ; Diabetic Retinopathy - pathology ; Edema ; Eye diseases ; Eye Proteins - antagonists & inhibitors ; Eye Proteins - metabolism ; Humans ; IL-1β ; Immunology ; Inflammation ; Inflammation - drug therapy ; Inflammation - metabolism ; Inflammation - pathology ; Integrins ; Interleukin-1beta - antagonists & inhibitors ; Interleukin-1beta - metabolism ; Interleukin-6 - antagonists & inhibitors ; Interleukin-6 - metabolism ; Internal Medicine ; Kallikrein ; Macular Edema - drug therapy ; Macular Edema - metabolism ; Macular Edema - pathology ; Plasma kallikrein ; Retina ; Retinal Vessels - metabolism ; Retinal Vessels - pathology ; Retinopathy ; Review ; Vascularization
Is Part Of: Seminars in immunopathology, 2019-07, Vol.41 (4), p.427-445
Description: Mounting evidence suggests that immunological mechanisms play a fundamental role in the pathogenesis of diabetic retinopathy (DR) and diabetic macular edema (DME). Upregulation of cytokines and other proinflammatory mediators leading to persistent low-grade inflammation is believed to actively contribute to the DR-associated damage to the retinal vasculature, inducing breakdown of the blood-retinal barrier, subsequent macular edema formation, and promotion of retinal neovascularization. This review summarizes the current knowledge of the biological processes providing an inflammatory basis for DR and DME. In addition, emerging therapeutic approaches targeting inflammation are discussed, including blockade of angiopoietin 2 and other molecular targets such as interleukin (IL)-6, IL-1β, plasma kallikrein, and integrins.
Publisher: Berlin/Heidelberg: Springer Berlin Heidelberg
Language: English
Identifier: ISSN: 1863-2297
EISSN: 1863-2300
DOI: 10.1007/s00281-019-00750-7
PMID: 31175392
Source: AUTh Library subscriptions: ProQuest Central
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The role of inflammation in diabetic eye disease

Springer-Verlag GmbH Germany, part of Springer Nature 2019 ;Seminars in Immunopathology is a copyright of Springer, (2019). All Rights Reserved. ;ISSN: 1863-2297 ;EISSN: 1863-2300 ;DOI: 10.1007/s00281-019-00750-7 ;PMID: 31175392

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