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Chemosensitivity of human melanoma xenografts in immunocompetent mice and its histological evaluation

International journal of cancer, 1984-04, Vol.33 (4), p.447-451 [Peer Reviewed Journal]

Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company ;1985 INIST-CNRS ;ISSN: 0020-7136 ;EISSN: 1097-0215 ;DOI: 10.1002/ijc.2910330405 ;PMID: 6706432 ;CODEN: IJCNAW

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Title:
Chemosensitivity of human melanoma xenografts in immunocompetent mice and its histological evaluation
Author: Dumont, P. ; Esch, E. P. Vander ; Jabri, M. ; Lejeune, F. ; Atassi, G.
Subjects: Animals ; Antineoplastic agents ; Antineoplastic Agents - pharmacology ; Antineoplastic Agents - therapeutic use ; Biological and medical sciences ; Drug Resistance ; General aspects ; Graft Survival ; Humans ; Immunocompetence ; Medical sciences ; Melanoma - drug therapy ; Melanoma - immunology ; Melanoma - pathology ; Mice ; Neoplasm Transplantation ; Pharmacology. Drug treatments ; Skin Neoplasms - drug therapy ; Skin Neoplasms - immunology ; Skin Neoplasms - pathology ; Transplantation, Heterologous
Is Part Of: International journal of cancer, 1984-04, Vol.33 (4), p.447-451
Description: In the subrenal capsule assay, the immuno‐competent mice used have a host immune response to the graft which may introduce a bias in the determination of tumour size. A study was therefore conducted to verify the quality of the correlation that could exist between “macroscopical” and “microscopical” evaluation. A histological study of 12 different tumours treated with cis‐Pt, L‐PAM, DTIC, vindesine, BCNU or TGU demonstrated that a cellular host immune response was observed in 11 out of the 12 control groups and was uneven in the treated groups. The “microscopical” and “macroscopical” evaluations of tumour‐take were 100 and 95% respectively. Although there was a fair correlation between the “microscopic” and “macroscopic” parameters, tumour variations in absence of host reaction ‐ which reflect pure chemosensitivity of the treated tissue ‐ could be measured in 50% of the cases. It was possible to determine abase‐line for rejection of the test results when the control group showed a decrease in mean tumour size exceeding 20% of its initial size on day 0. If the decrease is less than 20%, then the histological evaluation appears to be of considerable additional value.
Publisher: New York: Wiley Subscription Services, Inc., A Wiley Company
Language: English
Identifier: ISSN: 0020-7136
EISSN: 1097-0215
DOI: 10.1002/ijc.2910330405
PMID: 6706432
CODEN: IJCNAW
Source: MEDLINE
Alma/SFX Local Collection

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Chemosensitivity of human melanoma xenografts in immunocompetent mice and its histological evaluation

Copyright © 1984 Wiley‐Liss, Inc., A Wiley Company ;1985 INIST-CNRS ;ISSN: 0020-7136 ;EISSN: 1097-0215 ;DOI: 10.1002/ijc.2910330405 ;PMID: 6706432 ;CODEN: IJCNAW

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