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Very late-onset endocarditis complicated by non-significant aortic regurgitation after device closure of perimembranous ventricular septal defect

Medicine (Baltimore), 2020-05, Vol.99 (19), p.e20120-e20120 [Peer Reviewed Journal]

Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000020120 ;PMID: 32384490

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  • Title:
    Very late-onset endocarditis complicated by non-significant aortic regurgitation after device closure of perimembranous ventricular septal defect
  • Author: Tang, Changqing ; Zhou, Kaiyu ; Hua, Yimin ; Wang, Chuan
  • Subjects: Adolescent ; Aortic Valve Insufficiency - complications ; Cardiac Catheterization - methods ; Clinical Case Report ; Endocarditis - complications ; Endocarditis - drug therapy ; Endocarditis - surgery ; Heart Septal Defects, Ventricular - surgery ; Humans ; Male ; Septal Occluder Device ; Staphylococcal Infections - complications ; Tricuspid Valve - pathology
  • Is Part Of: Medicine (Baltimore), 2020-05, Vol.99 (19), p.e20120-e20120
  • Description: Aortic regurgitation (AR) was recognized as a major, but rare complication after device closure for perimembranous ventricular septal defects (PmVSD). Most of them are temporary and non-significant. Infectious endocarditis (IE) is another extremely rare post-procedure complication of PmVSD. Theoretically, AR could increase risk for post-interventional IE. However, no cases have been documented thus far. We firstly described a case of very late-onset IE associated with non-significant AR after transcatheter closure of PmVSD with modified symmetrical double-disk device, underscoring the need for reassessing long-term prognostic implications of non-significant post-procedure AR after PmVSD occlusion and the most appropriate treatment strategy. A 15-year old male received transcatheter closure of a 6.4 mm sized PmVSD with a 9-mm modified symmetric double-disk occluder (SHAMA) 11 years ago in our hospital. A new-onset mild eccentric AR was noted on transthoracic echocardiography (TTE) examination 1-year post procedure, without progression and heart enlargement. At this time, the child was admitted with a complaint of persistent fever for 16 days and nonresponse to 2-weeks course of amoxicillin and cefoxitin. The diagnosis of post-procedure IE was established since a vegetation (14 × 4 mm) was found to be attached to the tricuspid valve, an anechoic area (8 × 7 mm) on left upper side of ventricular septum and below right aortic sinus, and severe eccentric AR as well as the isolation of Staphylococcus aureus from all three-blood cultures. Treatment with vancomycin was initially adopted. However, surgical interventions including removal of vegetation, abscess and occluder, closure of VSD with a pericardial patch, tricuspid valvuloplasty, and aortic valvuloplasty were ultimately performed because of recurrent fever and a new-onset complete atrioventricular block 12-days later. The child continued with antibiotic therapy up to six weeks post operation. The child's temperature gradually returned to normal with alleviation of AR (mild) and heart block (first degree). The following course was uneventful. Late-onset IE could occur following device closure of PmVSD and be associated with post-procedure AR. For non-significant AR after device closure of PmVSD, early surgical intervention could be an alternative for reducing the aggravation of aortic valve damage and the risk of associated IE.
  • Publisher: United States: Wolters Kluwer Health
  • Language: English
  • Identifier: ISSN: 0025-7974
    EISSN: 1536-5964
    DOI: 10.1097/MD.0000000000020120
    PMID: 32384490
  • Source: IngentaConnect Free/Open Access Journals
    Journals@Ovid Open Access Journal Collection Rolling
    Wolters Kluwer Open Health
    MEDLINE
    PubMed Central
    DOAJ Directory of Open Access Journals
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