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Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis

Developmental cell, 2018-02, Vol.44 (3), p.284-296 [Peer Reviewed Journal]

2018 Elsevier Inc. ;Copyright © 2018 Elsevier Inc. All rights reserved. ;ISSN: 1534-5807 ;EISSN: 1878-1551 ;DOI: 10.1016/j.devcel.2018.01.009 ;PMID: 29408235

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  • Title:
    Cell Extrusion: A Stress-Responsive Force for Good or Evil in Epithelial Homeostasis
  • Author: Ohsawa, Shizue ; Vaughen, John ; Igaki, Tatsushi
  • Subjects: Animals ; apoptosis ; cancer ; cell competition ; cell extrusion ; Cell Physiological Phenomena ; Cell Survival ; development ; epithelia ; Epithelial Cells - cytology ; Epithelial Cells - physiology ; epithelial-mesenchymal transition ; Homeostasis ; Humans ; morphogenesis ; Morphogenesis - physiology ; Stress, Physiological ; tissue homeostasis
  • Is Part Of: Developmental cell, 2018-02, Vol.44 (3), p.284-296
  • Description: Epithelial tissues robustly respond to internal and external stressors via dynamic cellular rearrangements. Cell extrusion acts as a key regulator of epithelial homeostasis by removing apoptotic cells, orchestrating morphogenesis, and mediating competitive cellular battles during tumorigenesis. Here, we delineate the diverse functions of cell extrusion during development and disease. We emphasize the expanding role for apoptotic cell extrusion in exerting morphogenetic forces, as well as the strong intersection of cell extrusion with cell competition, a homeostatic mechanism that eliminates aberrant or unfit cells. While cell competition and extrusion can exert potent, tumor-suppressive effects, dysregulation of either critical homeostatic program can fuel cancer progression. Epithelial tissues robustly respond to internal and external stressors via dynamic cellular rearrangements. Cell extrusion acts as a key regulator of epithelial homeostasis by removing apoptotic cells, orchestrating morphogenesis, and mediating competitive cellular battles during tumorigenesis. Ohsawa et al. delineate the diverse functions of cell extrusion during development and disease.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 1534-5807
    EISSN: 1878-1551
    DOI: 10.1016/j.devcel.2018.01.009
    PMID: 29408235
  • Source: MEDLINE
    Cell Press Archives
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