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Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients

BMC cardiovascular disorders, 2021-01, Vol.21 (1), p.23-23, Article 23 [Peer Reviewed Journal]

COPYRIGHT 2021 BioMed Central Ltd. ;2021. This work is licensed under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2021 ;ISSN: 1471-2261 ;EISSN: 1471-2261 ;DOI: 10.1186/s12872-020-01816-3 ;PMID: 33413093

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Title:
Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients
Author: Silverio, Angelo ; Di Maio, Marco ; Citro, Rodolfo ; Esposito, Luca ; Iuliano, Giuseppe ; Bellino, Michele ; Baldi, Cesare ; De Luca, Giuseppe ; Ciccarelli, Michele ; Vecchione, Carmine ; Galasso, Gennaro
Subjects: Age ; Age Factors ; Analysis of Variance ; Cardiovascular disease ; Cardiovascular diseases ; Cardiovascular Diseases - etiology ; Cardiovascular Diseases - mortality ; Cardiovascular risk factors ; Coronaviruses ; COVID-19 ; COVID-19 - mortality ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus - mortality ; Fatalities ; Female ; Hospital Mortality ; Hospital patients ; Hospitalization ; Humans ; Hypertension ; Hypertension - mortality ; Hypotheses ; Male ; Meta-analysis ; Mortality ; Novel coronavirus ; Observational Studies as Topic ; Patient outcomes ; Publication Bias ; Regression Analysis ; Risk Factors ; SARS-CoV-2 ; Severe acute respiratory syndrome coronavirus 2 ; Sex Factors ; Smoking ; Smoking - mortality ; Statistics ; Tobacco
Is Part Of: BMC cardiovascular disorders, 2021-01, Vol.21 (1), p.23-23, Article 23
Description: A high prevalence of cardiovascular risk factors including age, male sex, hypertension, diabetes, and tobacco use, has been reported in patients with Coronavirus disease 2019 (COVID-19) who experienced adverse outcome. The aim of this study was to investigate the relationship between cardiovascular risk factors and in-hospital mortality in patients with COVID-19. MEDLINE, Cochrane, Web of Sciences, and SCOPUS were searched for retrospective or prospective observational studies reporting data on cardiovascular risk factors and in-hospital mortality in patients with COVID-19. Univariable and multivariable age-adjusted analyses were conducted to evaluate the association between cardiovascular risk factors and the occurrence of in-hospital death. The analysis included 45 studies enrolling 18,300 patients. The pooled estimate of in-hospital mortality was 12% (95% CI 9-15%). The univariable meta-regression analysis showed a significant association between age (coefficient: 1.06; 95% CI 1.04-1.09; p < 0.001), diabetes (coefficient: 1.04; 95% CI 1.02-1.07; p < 0.001) and hypertension (coefficient: 1.01; 95% CI 1.01-1.03; p = 0.013) with in-hospital death. Male sex and smoking did not significantly affect mortality. At multivariable age-adjusted meta-regression analysis, diabetes was significantly associated with in-hospital mortality (coefficient: 1.02; 95% CI 1.01-1.05; p = 0.043); conversely, hypertension was no longer significant after adjustment for age (coefficient: 1.00; 95% CI 0.99-1.01; p = 0.820). A significant association between age and in-hospital mortality was confirmed in all multivariable models. This meta-analysis suggests that older age and diabetes are associated with higher risk of in-hospital mortality in patients infected by SARS-CoV-2. Conversely, male sex, hypertension, and smoking did not independently correlate with fatal outcome.
Publisher: England: BioMed Central Ltd
Language: English
Identifier: ISSN: 1471-2261
EISSN: 1471-2261
DOI: 10.1186/s12872-020-01816-3
PMID: 33413093
Source: Open Access: DOAJ Directory of Open Access Journals
Directory of Open Access Scholarly Resources (ROAD)
Open Access: PubMed Central
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
MEDLINE
Springer Nature Open Access Journals
Coronavirus Research Database

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Cardiovascular risk factors and mortality in hospitalized patients with COVID-19: systematic review and meta-analysis of 45 studies and 18,300 patients

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