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Significant association of SYNTAX score on release of cardiac biomarkers in uncomplicated post-revascularization procedures among patients with stable multivessel disease: MASS-V Study group

Medicine (Baltimore), 2020-02, Vol.99 (8), p.e18973-e18973 [Peer Reviewed Journal]

Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000018973 ;PMID: 32080075

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Title:
Significant association of SYNTAX score on release of cardiac biomarkers in uncomplicated post-revascularization procedures among patients with stable multivessel disease: MASS-V Study group
Author: de Azevedo, Diogo Freitas Cardoso ; Hueb, Whady ; Lima, Eduardo Gomes ; Rezende, Paulo Cury ; Linhares Filho, Jaime Paula Pessoa ; de Carvalho, Guilherme Fernandes ; Martins, Eduardo Bello ; Nomura, Cesar Higa ; Strunz, Celia Maria Cassaro ; Serrano Junior, Carlos Vicente ; Ramires, Jose Antonio Franchini ; Kalil Filho, Roberto
Subjects: Aged ; Angioplasty - methods ; Atherosclerosis - metabolism ; Atherosclerosis - pathology ; Biomarkers - metabolism ; Cardiac Surgical Procedures - methods ; Coronary Angiography - methods ; Coronary Angiography - trends ; Coronary Artery Bypass - methods ; Coronary Artery Disease - blood ; Coronary Artery Disease - diagnostic imaging ; Coronary Artery Disease - pathology ; Coronary Artery Disease - surgery ; Female ; Humans ; Male ; Middle Aged ; Myocardial Infarction - diagnosis ; Myocardial Infarction - metabolism ; Myocardial Infarction - therapy ; Observational Study ; Percutaneous Coronary Intervention - methods ; Prospective Studies ; Troponin I - metabolism
Is Part Of: Medicine (Baltimore), 2020-02, Vol.99 (8), p.e18973-e18973
Description: This study investigated the relationship between angiographic complexities of coronary artery disease (CAD) assessed by SYNTAX Score synergy between percutaneous coronary intervention with taxus and cardiac surgery score (SYNTAX Score) and cardiac biomarker elevation after revascularization procedures.This is a post-hoc analysis of the medicine, angioplasty or surgery study V study of patients with stable CAD. High-sensitivity troponin 1 (hs-TnI) and creatinine kinase-muscle/brain (CK-MB) were assessed before and after cardiovascular procedures. Baselines SYNTAX Scores (SXScores) were calculated by blinded investigators to patient characteristics.Of the 202 patients studied, the mean SXScore was 21.25 ± 9.24; 40.10 ± 7.09 in the high SXScore group and 19.06 ± 6.61 in low/mid SXscore group (P < .0001). Positive correlations existed between SXScore and median peaks after procedural hs-TnI (r = 0.18, P = .009) and CK-MB (r = 0.24, P = .001) levels. In patients with high SXScores (≥33), the median peaks of post-procedural hs-TnI (P = .034)and CK-MB (P = .004) levels were higher than in low/mid SXScore group (<33).The release of hs-TnI at 6 (P = .002), 12 (P = .008), and 24 hours (P = .039) was higher in high SXScore group than in low/mid SXscore group (<33) as was the release of CK-MB at 6 (P < .0001), 12 (P < .0001), 24 (P = .001), 36 (P = .007), 48 (P = .008), and 72 hours (P = .023). After multivariable analysis, high SXScore was a significant independent predictor of release of CK-MB and hs-TnI peaks higher than the median.The increase in release of cardiac biomarkers was significantly associated with the extent of atherosclerosis identified by the SYNTAX Score.
Publisher: United States: Wolters Kluwer Health
Language: English
Identifier: ISSN: 0025-7974
EISSN: 1536-5964
DOI: 10.1097/MD.0000000000018973
PMID: 32080075
Source: Journals@Ovid Open Access Journal Collection Rolling
Wolters Kluwer Open Health
MEDLINE
PubMed Central
IngentaConnect website
DOAJ Directory of Open Access Journals

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Significant association of SYNTAX score on release of cardiac biomarkers in uncomplicated post-revascularization procedures among patients with stable multivessel disease: MASS-V Study group

Copyright © 2020 the Author(s). Published by Wolters Kluwer Health, Inc. 2020 ;ISSN: 0025-7974 ;EISSN: 1536-5964 ;DOI: 10.1097/MD.0000000000018973 ;PMID: 32080075

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