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Chalcogenide glass optical waveguides for infrared biosensing

Sensors (Basel, Switzerland), 2009-09, Vol.9 (9), p.7398-7411 [Peer Reviewed Journal]

Copyright MDPI AG 2009 ;Distributed under a Creative Commons Attribution 4.0 International License ;2009 by the authors; licensee MDPI, Basel, Switzerland 2009 ;ISSN: 1424-8220 ;EISSN: 1424-8220 ;DOI: 10.3390/s90907398 ;PMID: 22423209

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  • Title:
    Chalcogenide glass optical waveguides for infrared biosensing
  • Author: Anne, Marie-Laure ; Keirsse, Julie ; Nazabal, Virginie ; Hyodo, Koji ; Inoue, Satoru ; Boussard-Pledel, Catherine ; Lhermite, Hervé ; Charrier, Joël ; Yanakata, Kiyoyuki ; Loreal, Olivier ; Le Person, Jenny ; Colas, Florent ; Compère, Chantal ; Bureau, Bruno
  • Subjects: chalcogenide ; Chemical Sciences ; Engineering Sciences ; fibre ; Material chemistry ; Micro and nanotechnologies ; Microelectronics ; optical sensor ; planar waveguide
  • Is Part Of: Sensors (Basel, Switzerland), 2009-09, Vol.9 (9), p.7398-7411
  • Description: Due to the remarkable properties of chalcogenide (Chg) glasses, Chg optical waveguides should play a significant role in the development of optical biosensors. This paper describes the fabrication and properties of chalcogenide fibres and planar waveguides. Using optical fibre transparent in the mid-infrared spectral range we have developed a biosensor that can collect information on whole metabolism alterations, rapidly and in situ. Thanks to this sensor it is possible to collect infrared spectra by remote spectroscopy, by simple contact with the sample. In this way, we tried to determine spectral modifications due, on the one hand, to cerebral metabolism alterations caused by a transient focal ischemia in the rat brain and, in the other hand, starvation in the mouse liver. We also applied a microdialysis method, a well known technique for in vivo brain metabolism studies, as reference. In the field of integrated microsensors, reactive ion etching was used to pattern rib waveguides between 2 and 300 μm wide. This technique was used to fabricate Y optical junctions for optical interconnections on chalcogenide amorphous films, which can potentially increase the sensitivity and stability of an optical micro-sensor. The first tests were also carried out to functionalise the Chg planar waveguides with the aim of using them as (bio)sensors.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 1424-8220
    EISSN: 1424-8220
    DOI: 10.3390/s90907398
    PMID: 22423209
  • Source: DOAJ : Directory of Open Access Journals
    Directory of Open Access Scholarly Resources (ROAD)
    PubMed Central (Open access)
    Hyper Article en Ligne (HAL) (Open Access)
    GFMER Free Medical Journals
    ProQuest Central
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