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The Triterpenoids from IMunronia pinnata/I and Their Anti-Proliferative Effects

Molecules (Basel, Switzerland), 2023-09, Vol.28 (19) [Peer Reviewed Journal]

COPYRIGHT 2023 MDPI AG ;ISSN: 1420-3049 ;EISSN: 1420-3049 ;DOI: 10.3390/molecules28196839

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  • Title:
    The Triterpenoids from IMunronia pinnata/I and Their Anti-Proliferative Effects
  • Author: Yang, Xuerong ; Liu, Peiyuan ; Wei, Yulu ; Song, Jingru ; Yan, Xiaojie ; Jiang, Xiaohua ; Li, Jianxing ; Li, Xiangqin ; Li, Dianpeng ; Lu, Fenglai
  • Subjects: Instrument industry
  • Is Part Of: Molecules (Basel, Switzerland), 2023-09, Vol.28 (19)
  • Description: Six new tirucallane-type triterpenoids, named munropenes A–F (1–6), were extracted from the whole plants of Munronia pinnata using a water extraction method. Their chemical structures were determined based on detailed spectroscopic data. The relative configurations of the acyclic structures at C-17 of munropenes A–F (1–6) were established using carbon–proton spin-coupling constants ([sup.2,3]J[sub.C,H]) and inter-proton spin-coupling constants ([sup.3]J[sub.H,H]). Furthermore, the absolute configurations of munropenes A–F (1–6) were determined through high-performance liquid chromatography (HPLC), single-crystal X-ray diffraction, and electronic circular dichroism (ECD) analyses. The antiproliferative effects of munropenes A–F were evaluated in five tumor cell lines: HCT116, A549, HepG2, MCF7, and MDAMB. Munropenes A, B, D, and F (1, 2, 4, and 6) inhibited proliferation in the HCT116 cell line with IC[sub.50] values of 40.90, 19.13, 17.66, and 32.62 µM, respectively.
  • Publisher: MDPI AG
  • Language: English
  • Identifier: ISSN: 1420-3049
    EISSN: 1420-3049
    DOI: 10.3390/molecules28196839
  • Source: GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
    ProQuest Central
    DOAJ Directory of Open Access Journals
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