skip to main content
Language:
Search Limited to: Search Limited to: Resource type Show Results with: Show Results with: Search type Index

Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders

Frontiers in neuroscience, 2022-02, Vol.16, p.836605-836605 [Peer Reviewed Journal]

Copyright © 2022 Padhi, Worth, Zenitsky, Jin, Sambamurti, Anantharam, Kanthasamy and Kanthasamy. ;Copyright © 2022 Padhi, Worth, Zenitsky, Jin, Sambamurti, Anantharam, Kanthasamy and Kanthasamy. 2022 Padhi, Worth, Zenitsky, Jin, Sambamurti, Anantharam, Kanthasamy and Kanthasamy ;ISSN: 1662-4548 ;ISSN: 1662-453X ;EISSN: 1662-453X ;DOI: 10.3389/fnins.2022.836605 ;PMID: 35281490

Full text available

Citations Cited by
  • Title:
    Mechanistic Insights Into Gut Microbiome Dysbiosis-Mediated Neuroimmune Dysregulation and Protein Misfolding and Clearance in the Pathogenesis of Chronic Neurodegenerative Disorders
  • Author: Padhi, Piyush ; Worth, Carter ; Zenitsky, Gary ; Jin, Huajun ; Sambamurti, Kumar ; Anantharam, Vellareddy ; Kanthasamy, Arthi ; Kanthasamy, Anumantha G
  • Subjects: gut metabolome ; gut microbiota ; microbiome ; neurodegeneration ; neuroinflammation ; Neuroscience ; protein aggregation
  • Is Part Of: Frontiers in neuroscience, 2022-02, Vol.16, p.836605-836605
  • Description: The human gut microbiota is a complex, dynamic, and highly diverse community of microorganisms. Beginning as early as fetal development and continuing through birth to late-stage adulthood, the crosstalk between the gut microbiome and brain is essential for modulating various metabolic, neurodevelopmental, and immune-related pathways. Conversely, microbial dysbiosis - defined as alterations in richness and relative abundances - of the gut is implicated in the pathogenesis of several chronic neurological and neurodegenerative disorders. Evidence from large-population cohort studies suggests that individuals with neurodegenerative conditions have an altered gut microbial composition as well as microbial and serum metabolomic profiles distinct from those in the healthy population. Dysbiosis is also linked to psychiatric and gastrointestinal complications - comorbidities often associated with the prodromal phase of Parkinson's disease (PD) and Alzheimer's disease (AD). Studies have identified potential mediators that link gut dysbiosis and neurological disorders. Recent findings have also elucidated the potential mechanisms of disease pathology in the enteric nervous system prior to the onset of neurodegeneration. This review highlights the functional pathways and mechanisms, particularly gut microbe-induced chronic inflammation, protein misfolding, propagation of disease-specific pathology, defective protein clearance, and autoimmune dysregulation, linking gut microbial dysbiosis and neurodegeneration. In addition, we also discuss how pathogenic transformation of microbial composition leads to increased endotoxin production and fewer beneficial metabolites, both of which could trigger immune cell activation and enteric neuronal dysfunction. These can further disrupt intestinal barrier permeability, aggravate the systemic pro-inflammatory state, impair blood-brain barrier permeability and recruit immune mediators leading to neuroinflammation and neurodegeneration. Continued biomedical advances in understanding the microbiota-gut-brain axis will extend the frontier of neurodegenerative disorders and enable the utilization of novel diagnostic and therapeutic strategies to mitigate the pathological burden of these diseases.
  • Publisher: Switzerland: Frontiers Media S.A
  • Language: English
  • Identifier: ISSN: 1662-4548
    ISSN: 1662-453X
    EISSN: 1662-453X
    DOI: 10.3389/fnins.2022.836605
    PMID: 35281490
  • Source: Freely Accessible Journals
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
Back to results list
INSPIRE LIBRARY - TON DUC THANG UNIVERSITY (84-028) 37 755 057 Feedback
19 Nguyen Huu Tho St. Dist.7, HCM thuvien@tdtu.edu.vn

Copyright © 2017 INSPIRE LIBRARY - TON DUC THANG UNIVERSITY

Searching Remote Databases, Please Wait