Language:

Study of 27 Aqueous Humor Cytokines in Type 2 Diabetic Patients with or without Macular Edema

PloS one, 2015-04, Vol.10 (4), p.e0125329-e0125329 [Peer Reviewed Journal]

2015 Dong et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2015 Dong et al 2015 Dong et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0125329 ;PMID: 25923230

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Study of 27 Aqueous Humor Cytokines in Type 2 Diabetic Patients with or without Macular Edema
Author: Dong, Ning ; Xu, Bing ; Chu, Liqun ; Tang, Xin
Ablonczy, Zsolt
Subjects: Aged ; Angiogenesis ; Antiangiogenic agents ; Antiangiogenics ; Aqueous Humor - metabolism ; Cataracts ; Cloning ; Cytokines ; Cytokines - biosynthesis ; Cytokines - genetics ; Diabetes ; Diabetes mellitus ; Diabetes Mellitus, Type 2 - complications ; Diabetes Mellitus, Type 2 - genetics ; Diabetes Mellitus, Type 2 - pathology ; Diabetic retinopathy ; Diabetic Retinopathy - etiology ; Diabetic Retinopathy - genetics ; Diabetic Retinopathy - pathology ; Edema ; Eye surgery ; Female ; Humans ; Immunoassay ; Inflammation ; Interleukin 10 ; Interleukin 12 ; Interleukin 6 ; Interleukin 8 ; IP-10 protein ; Ischemia ; Macular Edema - etiology ; Macular Edema - genetics ; Macular Edema - pathology ; Male ; Middle Aged ; Monocyte chemoattractant protein 1 ; Multiplexing ; Pathogenesis ; Patients ; Permeability ; Retina ; Vascular endothelial growth factor
Is Part Of: PloS one, 2015-04, Vol.10 (4), p.e0125329-e0125329
Description: The aim of the present study was to compare the changes in the levels of 27 aqueous humor cytokines between diabetic patients with macular edema (ME) and diabetic patients without ME. Undiluted aqueous humor samples were obtained from 68 consecutive type 2 diabetic patients without ME and 56 consecutive type 2 diabetic patients with ME. The concentrations of 27 cytokines in the aqueous humor samples were measured using a multiplex bead immunoassay. Compared with diabetic patients without ME, diabetic patients with ME had significantly higher concentrations of IL-1β, IL-6, IL-8, IP-10, MCP-1, and VEGF in the aqueous humor. However, the concentrations of IL-10 and IL-12 were significantly lower in the diabetic patients with ME. The aqueous humor levels of IL-1β, IL-6, IL-8, MCP-1, IP-10, and VEGF were closely correlated with retinal macular thickness, retinal macular volume and the severity of ME. In addition, the aqueous humor levels of IL-10 and IL-12 decreased with increasing the severity of ME. A variety of cytokines associated with inflammation and angiogenesis may contribute to the pathogenesis of diabetic macular edema, and both anti-inflammatory and antiangiogenic agents should be included in the treatment of ME simultaneously.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0125329
PMID: 25923230
Source: Open Access: DOAJ Directory of Open Access Journals
Public Library of Science (PLoS) Journals Open Access
Open Access: PubMed Central
AUTh Library subscriptions: ProQuest Central
GFMER Free Medical Journals
MEDLINE

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Study of 27 Aqueous Humor Cytokines in Type 2 Diabetic Patients with or without Macular Edema

Searching Remote Databases, Please Wait