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Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats

Drug design, development and therapy, 2018, Vol.12, p.2267-2276 [Peer Reviewed Journal]

2018. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2018 Lin et al. This work is published and licensed by Dove Medical Press Limited 2018 ;ISSN: 1177-8881 ;EISSN: 1177-8881 ;DOI: 10.2147/DDDT.S173371 ;PMID: 30087551

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Title:
Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats
Author: Lin, Renjin ; Lin, Jinti ; Li, Shihen ; Ding, Jian ; Wu, Hongqiang ; Xiang, Guangheng ; Li, Shi ; Huang, Yijia ; Lin, Dingsheng ; Gao, Weiyang ; Kong, Jianzhong ; Xu, Huazi ; Zhou, Kailiang
Subjects: Angiogenesis ; Animals ; Apoptosis ; Apoptosis - drug effects ; Baicalein ; Biotechnology ; Blood vessels ; Caspase ; Caspase-3 ; Edema ; Edema - drug therapy ; Edema - metabolism ; Edema - pathology ; Flaps ; Flavanones - pharmacology ; Flavonoids ; Gene expression ; Glutathione ; Growth factors ; Herbal medicine ; Hybridization ; Immunoglobulins ; Ischemia ; Kinases ; Levels ; Male ; Malondialdehyde ; Medicine, Chinese Traditional ; Moisture content ; Necrosis ; Original Research ; Oxidation ; Oxidative stress ; Oxidative Stress - drug effects ; Plastic surgery ; random skin flap ; Rats ; Rats, Sprague-Dawley ; Reconstructive surgery ; Rodents ; Skin ; Skin - drug effects ; Surgery ; Surgical Flaps ; Survival ; Traditional Chinese medicine ; Transcription ; Vascular endothelial growth factor ; Viability ; Water content
Is Part Of: Drug design, development and therapy, 2018, Vol.12, p.2267-2276
Description: Random skin flaps are routinely placed during plastic and reconstructive surgery, but the distal areas often develop ischemia and necrosis. Baicalein, a major flavonoid extracted from the traditional Chinese herbal medicine huangqin, Georgi, may improve flap viability. Rats were randomly divided into baicalein and control groups and they underwent placement of modified McFarlane flaps after intraperitoneal administration of baicalein or vehicle. Flap survival and water content were measured 7 days later, as were angiogenesis, apoptosis, and oxidative stress in ischemic flaps. Baicalein promoted flap survival, reduced edema, increased mean vessel density, and enhanced vascular endothelial growth factor production at both the translational and transcriptional levels. Baicalein reduced caspase 3 cleavage, increased superoxidase dismutase and glutathione levels, and decreased the malondialdehyde level. Baicalein promoted flap viability by stimulating angiogenesis and inhibiting apoptosis and oxidation.
Publisher: New Zealand: Taylor & Francis Ltd
Language: English
Identifier: ISSN: 1177-8881
EISSN: 1177-8881
DOI: 10.2147/DDDT.S173371
PMID: 30087551
Source: Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
DOVE Medical Press OA Journals
MEDLINE
PubMed Central
ROAD: Directory of Open Access Scholarly Resources
DOAJ Directory of Open Access Journals

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Effects of the traditional Chinese medicine baicalein on the viability of random pattern skin flaps in rats

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