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Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

Neuropsychopharmacology (New York, N.Y.), 2010-10, Vol.35 (11), p.2143-2154 [Peer Reviewed Journal]

2015 INIST-CNRS ;Copyright Nature Publishing Group Oct 2010 ;Copyright © 2010 American College of Neuropsychopharmacology 2010 American College of Neuropsychopharmacology ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/npp.2010.105 ;PMID: 20668436 ;CODEN: NEROEW

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Title:
Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?
Author: XIAOHUA LI ; JOPE, Richard S
Subjects: Affect - drug effects ; Affect - physiology ; Animals ; Biological and medical sciences ; Brain - drug effects ; Brain - enzymology ; Glycogen Synthase Kinase 3 - antagonists & inhibitors ; Glycogen Synthase Kinase 3 - metabolism ; Glycogen Synthase Kinase 3 - physiology ; Humans ; Medical sciences ; Mood Disorders - diagnosis ; Mood Disorders - drug therapy ; Mood Disorders - enzymology ; Neuropharmacology ; Pharmacology. Drug treatments ; Protein Kinase Inhibitors - pharmacology ; Protein Kinase Inhibitors - therapeutic use ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer ; Psychoanaleptics: cns stimulant, antidepressant agent, nootropic agent, mood stabilizer..., (alzheimer disease) ; Psychology. Psychoanalysis. Psychiatry ; Psychopharmacology ; Review ; Signal Transduction - drug effects ; Signal Transduction - physiology
Is Part Of: Neuropsychopharmacology (New York, N.Y.), 2010-10, Vol.35 (11), p.2143-2154
Description: Little is known regarding the mechanisms underlying the complex etiology of mood disorders, represented mainly by major depressive disorder and bipolar disorder. The 1996 discovery that lithium inhibits glycogen synthase kinase-3 (GSK3) raised the possibility that impaired inhibition of GSK3 is associated with mood disorders. This is now supported by evidence from animal biochemical, pharmacological, molecular, and behavioral studies and from human post-mortem brain, peripheral tissue, and genetic studies that are reviewed here. Mood disorders may result in part from impairments in mechanisms controlling the activity of GSK3 or GSK3-regulated functions, and disruptions of these regulating systems at different signaling sites may contribute to the heterogeneity of mood disorders. This substantial evidence supports the conclusion that bolstering the inhibitory control of GSK3 is an important component of the therapeutic actions of drugs used to treat mood disorders and that GSK3 is a valid target for developing new therapeutic interventions.
Publisher: Basingstoke: Nature Publishing Group
Language: English
Identifier: ISSN: 0893-133X
EISSN: 1740-634X
DOI: 10.1038/npp.2010.105
PMID: 20668436
CODEN: NEROEW
Source: ProQuest One Psychology
Geneva Foundation Free Medical Journals at publisher websites
AUTh Library subscriptions: ProQuest Central
MEDLINE
PubMed Central

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Is Glycogen Synthase Kinase-3 a Central Modulator in Mood Regulation?

2015 INIST-CNRS ;Copyright Nature Publishing Group Oct 2010 ;Copyright © 2010 American College of Neuropsychopharmacology 2010 American College of Neuropsychopharmacology ;ISSN: 0893-133X ;EISSN: 1740-634X ;DOI: 10.1038/npp.2010.105 ;PMID: 20668436 ;CODEN: NEROEW

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