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Co‐occurrence of antibiotic, biocide, and heavy metal resistance genes in bacteria from metal and radionuclide contaminated soils at the Savannah River Site

Microbial biotechnology, 2020-07, Vol.13 (4), p.1179-1200 [Peer Reviewed Journal]

2020 The Authors. published by John Wiley & Sons Ltd and Society for Applied Microbiology. ;2020 The Authors. Microbial Biotechnology published by John Wiley & Sons Ltd and Society for Applied Microbiology. ;2020. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1751-7915 ;EISSN: 1751-7915 ;DOI: 10.1111/1751-7915.13578 ;PMID: 32363769

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Title:
Co‐occurrence of antibiotic, biocide, and heavy metal resistance genes in bacteria from metal and radionuclide contaminated soils at the Savannah River Site
Author: Thomas, Jesse C. ; Oladeinde, Adelumola ; Kieran, Troy J. ; Finger, John W. ; Bayona‐Vásquez, Natalia J. ; Cartee, John C. ; Beasley, James C. ; Seaman, John C. ; McArthur, J Vuan ; Rhodes, Olin E. ; Glenn, Travis C.
Subjects: Acidic soils ; Anti-Bacterial Agents - pharmacology ; Antibiotic resistance ; Antibiotics ; Antimicrobial agents ; Antimicrobial resistance ; Arsenic ; Bacteria ; Bacteria - genetics ; BASIC BIOLOGICAL SCIENCES ; Basins ; Biocides ; Biotechnology & Applied Microbiology ; Contaminants ; Contamination ; Disinfectants ; Drug resistance ; Gene sequencing ; Genes ; Genes, Bacterial ; Heavy metals ; Humans ; Metagenomics ; Metals, Heavy - toxicity ; Microbiology ; Nickel ; Radioisotopes ; Relative abundance ; Rivers ; RNA, Ribosomal, 16S - genetics ; rRNA 16S ; Savannahs ; Sediment pollution ; Soil ; Soil contamination ; Soil Microbiology ; Soil microorganisms ; Soil pollution ; Soil structure ; Soils ; Vancomycin ; Water pollution
Is Part Of: Microbial biotechnology, 2020-07, Vol.13 (4), p.1179-1200
Description: Summary Contaminants such as heavy metals may contribute to the dissemination of antimicrobial resistance (AMR) by enriching resistance gene determinants via co‐selection mechanisms. In the present study, a survey was performed on soils collected from four areas at the Savannah River Site (SRS), South Carolina, USA, with varying contaminant profiles: relatively pristine (Upper Three Runs), heavy metals (Ash Basins), radionuclides (Pond B) and heavy metal and radionuclides (Tim’s Branch). Using 16S rRNA gene amplicon sequencing, we explored the structure and diversity of soil bacterial communities. Sites with legacies of metal and/or radionuclide contamination displayed significantly lower bacterial diversity compared to the reference site. Metagenomic analysis indicated that multidrug and vancomycin antibiotic resistance genes (ARGs) and metal resistance genes (MRGs) including those associated with copper, arsenic, iron, nickel and zinc were prominent in all soils including the reference site. However, significant differences were found in the relative abundance and diversity of certain ARGs and MRGs in soils with metal/radionuclide contaminated soils compared to the reference site. Co‐occurrence patterns revealed significant ARG/MRG subtypes in predominant soil taxa including Acidobacteriaceae, Bradyrhizobium, Mycobacterium, Streptomyces, Verrumicrobium, Actinomadura and Solirubacterales. Overall, the study emphasizes the potential risk of human activities on the dissemination of AMR in the environment. We present a comprehensive analysis of the soil microbiome in several areas affected by legacies of heavy‐metal and radionuclide contamination. We explore how these contaminants affect bacterial community composition and diversity, and the enrichment of antibiotic, biocide, and metal‐resistance genes. We find that these contaminants can not only have a profound impact on soil microbiome composition, but it can also affect how it functions.
Publisher: United States: John Wiley & Sons, Inc
Language: English
Identifier: ISSN: 1751-7915
EISSN: 1751-7915
DOI: 10.1111/1751-7915.13578
PMID: 32363769
Source: Journals@Ovid Open Access Journal Collection Rolling
Geneva Foundation Free Medical Journals at publisher websites
MEDLINE
PubMed Central
Wiley Online Library Open Access
ProQuest Central
DOAJ Directory of Open Access Journals

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Co‐occurrence of antibiotic, biocide, and heavy metal resistance genes in bacteria from metal and radionuclide contaminated soils at the Savannah River Site

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