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The Role of Viperin in Antiflavivirus Responses

DNA and cell biology, 2018-09, Vol.37 (9), p.725-730 [Peer Reviewed Journal]

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Title:
The Role of Viperin in Antiflavivirus Responses
Author: Lindqvist, Richard ; Överby, Anna K
Subjects: antiviral response ; flavivirus ; Flavivirus - classification ; Flavivirus - physiology ; Humans ; Infections ; Interferon ; interferon-stimulated gene ; Proteins ; Proteins - chemistry ; Proteins - metabolism ; radical SAM enzyme ; viperin ; Viral infections ; Virus Diseases - immunology ; Virus Diseases - metabolism ; Virus Diseases - virology ; Virus Replication ; Viruses
Is Part Of: DNA and cell biology, 2018-09, Vol.37 (9), p.725-730
Description: Viperin is an interferon (IFN)-stimulated gene product, which is part of the first line of the intracellular response against viral infection. It is a potent antiviral protein, strongly upregulated after IFN-stimulation and virus infection. Viperin is antivirally active against many different viruses from different families and has been shown to inhibit several flaviviruses. Flaviviruses are an important group of arthropod-borne viruses that cause millions of infections annually. In this review, we focus on the recent advances of the antiviral mechanisms of viperin against these flaviviruses, both pointing to similarities and differences between viruses within the same genera.
Publisher: United States: Mary Ann Liebert, Inc
Language: English
Identifier: ISSN: 1044-5498
ISSN: 1557-7430
EISSN: 1557-7430
DOI: 10.1089/dna.2018.4328
PMID: 30059238
Source: MEDLINE
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