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Human immune system variation

Nature reviews. Immunology, 2017-01, Vol.17 (1), p.21-29 [Peer Reviewed Journal]

COPYRIGHT 2017 Nature Publishing Group ;COPYRIGHT 2017 Nature Publishing Group ;Copyright Nature Publishing Group Jan 2017 ;ISSN: 1474-1733 ;ISSN: 1474-1741 ;EISSN: 1474-1741 ;DOI: 10.1038/nri.2016.125 ;PMID: 27916977

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  • Title:
    Human immune system variation
  • Author: Brodin, Petter ; Davis, Mark M
  • Subjects: Communicable diseases ; Heredity ; Humans ; Immune response ; Immune System - physiology ; Medical research ; Medicin och hälsovetenskap ; Medicine, Experimental ; Observations ; Physiological aspects
  • Is Part Of: Nature reviews. Immunology, 2017-01, Vol.17 (1), p.21-29
  • Description: The human immune system is highly variable between individuals but relatively stable over time within a given person. Recent conceptual and technological advances have enabled systems immunology analyses, which reveal the composition of immune cells and proteins in populations of healthy individuals. The range of variation and some specific influences that shape an individual's immune system is now becoming clearer. Human immune systems vary as a consequence of heritable and non-heritable influences, but symbiotic and pathogenic microbes and other non-heritable influences explain most of this variation. Understanding when and how such influences shape the human immune system is key for defining metrics of immunological health and understanding the risk of immune-mediated and infectious diseases.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 1474-1733
    ISSN: 1474-1741
    EISSN: 1474-1741
    DOI: 10.1038/nri.2016.125
    PMID: 27916977
  • Source: AUTh Library subscriptions: ProQuest Central
    MEDLINE
    SWEPUB Freely available online
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