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Houttuynia cordata targets the beginning stage of herpes simplex virus infection

PloS one, 2015-02, Vol.10 (2), p.e0115475-e0115475 [Peer Reviewed Journal]

COPYRIGHT 2015 Public Library of Science ;COPYRIGHT 2015 Public Library of Science ;2015 Hung et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2015 Hung et al 2015 Hung et al ;ISSN: 1932-6203 ;EISSN: 1932-6203 ;DOI: 10.1371/journal.pone.0115475 ;PMID: 25643242

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Title:
Houttuynia cordata targets the beginning stage of herpes simplex virus infection
Author: Hung, Pei-Yun ; Ho, Bing-Ching ; Lee, Szu-Yuan ; Chang, Sui-Yuan ; Kao, Chuan-Liang ; Lee, Shoei-Sheng ; Lee, Chun-Nan
Sawtell, Nancy M
Subjects: Acyclovir ; Acyclovir - pharmacology ; Animals ; Antiviral Agents - isolation & purification ; Antiviral Agents - pharmacology ; Biotechnology ; Cell culture ; Cell Line ; Chinese medicine ; Drug development ; Drug resistance ; Drug Resistance, Viral - drug effects ; Drugs ; Encephalitis ; FDA approval ; Flavonoids ; Free radicals ; Gene expression ; Gene Expression Regulation, Viral - drug effects ; Health aspects ; Herbal medicine ; Herpes simplex ; Herpes simplex virus ; Herpes viruses ; Herpesvirus 1, Human - drug effects ; Herpesvirus 1, Human - genetics ; Herpesvirus 1, Human - metabolism ; Herpesvirus 1, Human - physiology ; Herpesvirus 2, Human - drug effects ; Herpesvirus 2, Human - genetics ; Herpesvirus 2, Human - metabolism ; Herpesvirus 2, Human - physiology ; HIV ; Hot Temperature ; Houttuynia - chemistry ; Houttuynia cordata ; Human immunodeficiency virus ; Humans ; Infection ; Infections ; Influenza ; Kinases ; Laboratories ; Meningitis ; Molecular chains ; Molecular modelling ; NF-kappa B - metabolism ; NF-κB protein ; Penetration resistance ; Plant Extracts - isolation & purification ; Plant Extracts - pharmacology ; Pneumonia ; Proteins ; Quercetin ; Viral Envelope Proteins - metabolism ; Viral infections ; Virion - drug effects ; Virion - physiology ; Virus diseases ; Virus Internalization - drug effects ; Virus replication ; Virus Replication - drug effects ; Viruses ; Water - chemistry
Is Part Of: PloS one, 2015-02, Vol.10 (2), p.e0115475-e0115475
Description: Herpes simplex virus (HSV), a common latent virus in humans, causes certain severe diseases. Extensive use of acyclovir (ACV) results in the development of drug-resistant HSV strains, hence, there is an urgent need to develop new drugs to treat HSV infection. Houttuynia cordata (H. cordata), a natural herbal medicine, has been reported to exhibit anti-HSV effects which is partly NF-κB-dependent. However, the molecular mechanisms by which H. cordata inhibits HSV infection are not elucidated thoroughly. Here, we report that H. cordata water extracts (HCWEs) inhibit the infection of HSV-1, HSV-2, and acyclovir-resistant HSV-1 mainly via blocking viral binding and penetration in the beginning of infection. HCWEs also suppress HSV replication. Furthermore, HCWEs attenuate the first-wave of NF-κB activation, which is essential for viral gene expressions. Further analysis of six compounds in HCWEs revealed that quercetin and isoquercitrin inhibit NF-κB activation and additionally, quercetin also has an inhibitory effect on viral entry. These results indicate that HCWEs can inhibit HSV infection through multiple mechanisms and could be a potential lead for development of new drugs for treating HSV.
Publisher: United States: Public Library of Science
Language: English
Identifier: ISSN: 1932-6203
EISSN: 1932-6203
DOI: 10.1371/journal.pone.0115475
PMID: 25643242
Source: PubMed Central (Open access)
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Geneva Foundation Free Medical Journals at publisher websites
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Coronavirus Research Database
ProQuest Central
DOAJ Directory of Open Access Journals

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Houttuynia cordata targets the beginning stage of herpes simplex virus infection

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