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Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease

Journal of inflammation research, 2021-01, Vol.14, p.2647-2666 [Peer Reviewed Journal]

2021 Ji et al. ;COPYRIGHT 2021 Dove Medical Press Limited ;2021. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 Ji et al. 2021 Ji et al. ;ISSN: 1178-7031 ;EISSN: 1178-7031 ;DOI: 10.2147/JIR.S308177 ;PMID: 34188515

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Title:
Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease
Author: Ji, Nan ; Qi, Zhongwen ; Wang, Yueyao ; Yang, Xiaoya ; Yan, Zhipeng ; Li, Meng ; Ge, Qihui ; Zhang, Junping
Subjects: Apoptosis ; Arrhythmia ; Arteriosclerosis ; Atherosclerosis ; Autophagy ; Cardiomyopathy ; cardiopathy ; Cardiovascular disease ; Cardiovascular diseases ; Caspase-1 ; Caspase-3 ; Caspase-4 ; Cell death ; Congestive heart failure ; Cytokines ; Cytology ; Cytoplasm ; Diabetes mellitus ; Heart attack ; Hypertension ; IL-1β ; Inflammation ; Interleukin 18 ; Ischemia ; Lysis ; Membranes ; Morphology ; Mucocutaneous lymph node syndrome ; Myocardial infarction ; nlrp3 ; Permeability ; Phagocytosis ; Physical characteristics ; Physiology ; Proteins ; pyroptosis ; Reperfusion ; Review ; Therapeutic targets
Is Part Of: Journal of inflammation research, 2021-01, Vol.14, p.2647-2666
Description: Pyroptosis is a kind of pro-inflammatory cell death. Compared with autophagy and apoptosis, pyroptosis has unique characteristics in morphology and mechanism. Specifically, pyroptosis is a kind of cell lysis mediated by the Gasdermin family, releases inflammatory cytokines IL-1β and IL-18. There are three different forms of mechanism, which are caspase-1-mediated, caspase-4/5/11-mediated and caspase-3-mediated. A large number of studies have proved that pyroptosis is closely related to cardiovascular disease. This paper reviewed the recent progress in the related research on pyroptosis and myocardial infarction, ischemia-reperfusion, atherosclerosis, diabetic cardiomyopathy, arrhythmia, heart failure hypertension and Kawasaki disease. Therefore, we believe that pyroptosis may be a new therapeutic target in the cardiovascular field.
Publisher: New Zealand: Dove Medical Press Limited
Language: English
Identifier: ISSN: 1178-7031
EISSN: 1178-7031
DOI: 10.2147/JIR.S308177
PMID: 34188515
Source: Open Access: PubMed Central
Geneva Foundation Free Medical Journals at publisher websites
Coronavirus Research Database
ROAD: Directory of Open Access Scholarly Resources
ProQuest Central
DOAJ Directory of Open Access Journals
Dove Press Free

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Pyroptosis: A New Regulating Mechanism in Cardiovascular Disease

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