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Long-COVID in children and adolescents: a systematic review and meta-analyses

Scientific reports, 2022-06, Vol.12 (1), p.9950-9950, Article 9950 [Peer Reviewed Journal]

The Author(s) 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2022 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-022-13495-5 ;PMID: 35739136

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  • Title:
    Long-COVID in children and adolescents: a systematic review and meta-analyses
  • Author: Lopez-Leon, Sandra ; Wegman-Ostrosky, Talia ; Ayuzo del Valle, Norma Cipatli ; Perelman, Carol ; Sepulveda, Rosalinda ; Rebolledo, Paulina A. ; Cuapio, Angelica ; Villapol, Sonia
  • Subjects: Adolescents ; Anosmia ; Children ; Coronaviruses ; COVID-19 ; Dyspnea ; Fever ; Medicin och hälsovetenskap ; Meta-analysis ; Olfaction disorders ; Respiration ; Severe acute respiratory syndrome coronavirus 2 ; Sleep disorders ; Statistical analysis ; Systematic review ; Taste disorders ; Teenagers
  • Is Part Of: Scientific reports, 2022-06, Vol.12 (1), p.9950-9950, Article 9950
  • Description: Abstract The objective of this systematic review and meta-analyses is to estimate the prevalence of long-COVID in children and adolescents and to present the full spectrum of symptoms present after acute COVID-19. We have used PubMed and Embase to identify observational studies published before February 10th, 2022 that included a minimum of 30 patients with ages ranging from 0 to 18 years that met the National Institute for Healthcare Excellence (NICE) definition of long-COVID, which consists of both ongoing (4 to 12 weeks) and post-COVID-19 (≥ 12 weeks) symptoms. Random-effects meta-analyses were performed using the MetaXL software to estimate the pooled prevalence with a 95% confidence interval (CI). Heterogeneity was assessed using I 2 statistics. The Preferred Reporting Items for Systematic Reviewers and Meta-analysis (PRISMA) reporting guideline was followed (registration PROSPERO CRD42021275408). The literature search yielded 8373 publications, of which 21 studies met the inclusion criteria, and a total of 80,071 children and adolescents were included. The prevalence of long-COVID was 25.24%, and the most prevalent clinical manifestations were mood symptoms (16.50%), fatigue (9.66%), and sleep disorders (8.42%). Children infected by SARS-CoV-2 had a higher risk of persistent dyspnea, anosmia/ageusia, and/or fever compared to controls. Limitations of the studies analyzed include lack of standardized definitions, recall, selection, misclassification, nonresponse and/or loss of follow-up, and a high level of heterogeneity.
  • Publisher: London: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 2045-2322
    EISSN: 2045-2322
    DOI: 10.1038/s41598-022-13495-5
    PMID: 35739136
  • Source: PubMed Central
    SWEPUB Freely available online
    Coronavirus Research Database
    ProQuest Central
    DOAJ Directory of Open Access Journals
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