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P387 STI incidence after STI treatment among women at risk for HIV exposure initiating safer conception care in southwestern Uganda

Sexually transmitted infections, 2021-07, Vol.97 (Suppl 1), p.A161-A161 [Peer Reviewed Journal]

Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. ;2021 Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. ;ISSN: 1368-4973 ;EISSN: 1472-3263 ;DOI: 10.1136/sextrans-2021-sti.422

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  • Title:
    P387 STI incidence after STI treatment among women at risk for HIV exposure initiating safer conception care in southwestern Uganda
  • Author: Chitneni, P ; Bwana, M ; Owembabazi, M ; O’Neil, K ; Kalyebara, P ; Muyindike, W ; Byamukama, A ; Mbalibulha, Y ; Wirth, K ; Bangsberg, D ; Marrazzo, J ; Haberer, J ; Kaida, A ; Matthews, L
  • Subjects: Pregnancy
  • Is Part Of: Sexually transmitted infections, 2021-07, Vol.97 (Suppl 1), p.A161-A161
  • Description: BackgroundSexually transmitted infection (STI) recurrence contributes to the high global STI burden. We introduced STI screening and facilitated partner notification (PN) and treatment among women participating in a safer conception study in southwestern Uganda to understand impacts on STI incidence.MethodsA parent study enrolled women planning for pregnancy with a man with HIV or of unknown serostatus to assess pre-exposure prophylaxis use for safer conception. STI screening began after study-start, and all eligible women completed screening for chlamydia, gonorrhea, and trichomoniasis via GeneXpert nucleic acid amplification testing and syphilis via immunochromatographic testing and rapid plasma reagin. Multivariable Poisson regression was used to determine incident STI correlates.ResultsOf 134 women in the parent study, 94 underwent enrollment STI screening, of whom 23 were positive. Median age was 31 (IQR 28–35) years. All participants with STIs received counseling and treatment; 21/23 participants accepted PN cards and 18/23 accepted patient-delivered partner medications. By the six-month study-visit, 81 participants repeated STI testing (N=66 at that visit, N=15 at incident pregnancy visit; whichever came first); 13 participants were lost to follow-up. Of those with enrollment STIs, 19/23 returned for follow-up at six months; 18 reported delivering PN cards and discussing STIs with partner(s) and 14 reported medication delivery to partner(s). Incident STIs occurred in 17/81 participants with 42.57 person-years of follow-up (incidence rate 40/100 person-years). STI incidence was associated with enrollment STI (incidence rate ratio [IRR] 3.39, 95% confidence interval [CI] 1.22–9.43) and alcohol consumption (IRR 3.18, 95% CI 1.15–8.85).ConclusionsWe demonstrate a high STI prevalence and incidence among women planning for pregnancy in Uganda despite partner treatment promotion efforts. These infections are likely driven in part by re-infection from untreated partners. Novel STI PN interventions are needed to decrease the STI burden, especially among women planning for and with pregnancy.
  • Publisher: London: BMJ Publishing Group LTD
  • Language: English
  • Identifier: ISSN: 1368-4973
    EISSN: 1472-3263
    DOI: 10.1136/sextrans-2021-sti.422
  • Source: AUTh Library subscriptions: ProQuest Central
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