Language:

Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?

Indian journal of endocrinology and metabolism, 2016-07, Vol.20 (4), p.546-551 [Peer Reviewed Journal]

COPYRIGHT 2016 Medknow Publications and Media Pvt. Ltd. ;Copyright Medknow Publications & Media Pvt Ltd Jul-Aug 2016 ;Copyright: © Indian Journal of Endocrinology and Metabolism 2016 ;ISSN: 2230-8210 ;EISSN: 2230-9500 ;DOI: 10.4103/2230-8210.183480 ;PMID: 27366724

Full text available

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?
Author: Chawla, Aastha ; Chawla, Rajeev ; Jaggi, Shalini
Subjects: Acute coronary syndromes ; Atherosclerosis ; Blood pressure ; Cardiomyopathy ; Cardiovascular disease ; Complications ; Complications and side effects ; Confidence intervals ; Development and progression ; Diabetes ; Diabetic neuropathy ; Diabetic retinopathy ; Epidemiology ; Glucose ; Heart attacks ; Hyperglycemia ; Hypertension ; Hypotheses ; Hypoxia ; Insulin ; Insulin resistance ; macrovascular ; Metabolism ; microvascular ; Mortality ; Permeability ; Researchers ; Review ; Risk factors ; Rodents ; Studies ; Type 2 diabetes ; Vascular diseases ; Vascular endothelial growth factor
Is Part Of: Indian journal of endocrinology and metabolism, 2016-07, Vol.20 (4), p.546-551
Description: Diabetes and related complications are associated with long-term damage and failure of various organ systems. The line of demarcation between the pathogenic mechanisms of microvascular and macrovascular complications of diabetes and differing responses to therapeutic interventions is blurred. Diabetes induces changes in the microvasculature, causing extracellular matrix protein synthesis, and capillary basement membrane thickening which are the pathognomic features of diabetic microangiopathy. These changes in conjunction with advanced glycation end products, oxidative stress, low grade inflammation, and neovascularization of vasa vasorum can lead to macrovascular complications. Hyperglycemia is the principal cause of microvasculopathy but also appears to play an important role in causation of macrovasculopathy. There is thought to be an intersection between micro and macro vascular complications, but the two disorders seem to be strongly interconnected, with micro vascular diseases promoting atherosclerosis through processes such as hypoxia and changes in vasa vasorum. It is thus imperative to understand whether microvascular complications distinctly precede macrovascular complications or do both of them progress simultaneously as a continuum. This will allow re-focusing on the clinical issues with a unifying perspective which can improve type 2 diabetes mellitus outcomes.
Publisher: India: Wolters Kluwer - Medknow Publications
Language: English
Identifier: ISSN: 2230-8210
EISSN: 2230-9500
DOI: 10.4103/2230-8210.183480
PMID: 27366724
Source: Geneva Foundation Free Medical Journals at publisher websites
Medknow Open Access Journals
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Microvasular and macrovascular complications in diabetes mellitus: Distinct or continuum?

COPYRIGHT 2016 Medknow Publications and Media Pvt. Ltd. ;Copyright Medknow Publications & Media Pvt Ltd Jul-Aug 2016 ;Copyright: © Indian Journal of Endocrinology and Metabolism 2016 ;ISSN: 2230-8210 ;EISSN: 2230-9500 ;DOI: 10.4103/2230-8210.183480 ;PMID: 27366724

Searching Remote Databases, Please Wait