Language:

Alcohol consumption in relation to cardiovascular diseases and mortality : a systematic review of Mendelian randomization studies

info:eu-repo/semantics/openAccess ;DOI: 10.1007/s10654-021-00799-5 ;PMID: 34420153

Digital Resources/Online E-Resources

Citations Cited by

Actions
1. Add to My Research
2. Remove from My Research
3. E-mail
4. Print
5. Permalink
6. Citation
7. EasyBib
8. EndNote
9. RefWorks
10. Delicious
11. Export RIS
12. Export BibTeX

Title:
Alcohol consumption in relation to cardiovascular diseases and mortality : a systematic review of Mendelian randomization studies
Author: van de Luitgaarden, Inge A T ; van Oort, Sabine ; Bouman, Emma J ; Schoonmade, Linda J ; Schrieks, Ilse C ; Grobbee, Diederick E ; van der Schouw, Yvonne T ; Larsson, Susanna C ; Burgess, Stephen ; van Ballegooijen, Adriana J ; Onland-Moret, N Charlotte ; Beulens, Joline W J
Subjects: Alcohol consumption ; Cardiovascular disease ; Cardiovascular risk factors ; Diabetes ; Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi ; Mendelian randomization ; Mortality ; Public Health, Global Health, Social Medicine and Epidemiology ; Systematic review
Description: The causal effects of alcohol-in-moderation on cardiometabolic health are continuously debated. Mendelian randomization (MR) is an established method to address causal questions in observational studies. We performed a systematic review of the current evidence from MR studies on the association between alcohol consumption and cardiometabolic diseases, all-cause mortality and cardiovascular risk factors. We performed a systematic search of the literature, including search terms on type of design and exposure. We assessed methodological quality based on key elements of the MR design: use of a full instrumental variable analysis and validation of the three key MR assumptions. We additionally looked at exploration of non-linearity. We reported the direction of the studied associations. Our search yielded 24 studies that were eligible for inclusion. A full instrumental variable analysis was performed in 17 studies (71%) and 13 out of 24 studies (54%) validated all three key assumptions. Five studies (21%) assessed potential non-linearity. In general, null associations were reported for genetically predicted alcohol consumption with the primary outcomes cardiovascular disease (67%) and diabetes (75%), while the only study on all-cause mortality reported a detrimental association. Considering the heterogeneity in methodological quality of the included MR studies, it is not yet possible to draw conclusions on the causal role of moderate alcohol consumption on cardiometabolic health. As MR is a rapidly evolving field, we expect that future MR studies, especially with recent developments regarding instrument selection and non-linearity methodology, will further substantiate this discussion.
Publisher: Uppsala universitet, Medicinsk epidemiologi
Creation Date: 2022
Language: English
Identifier: DOI: 10.1007/s10654-021-00799-5
PMID: 34420153
Source: Uppsala University DiVA

Back to results list


INSPIRE LIBRARY - TON DUC THANG UNIVERSITY	(84-028) 37 755 057	Feedback
19 Nguyen Huu Tho St. Dist.7, HCM	thuvien@tdtu.edu.vn	Feedback

Alcohol consumption in relation to cardiovascular diseases and mortality : a systematic review of Mendelian randomization studies

info:eu-repo/semantics/openAccess ;DOI: 10.1007/s10654-021-00799-5 ;PMID: 34420153

Searching Remote Databases, Please Wait