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Tumor organoid biobank-new platform for medical research

Scientific reports, 2023-02, Vol.13 (1), p.1819-1819, Article 1819 [Peer Reviewed Journal]

2023. The Author(s). ;The Author(s) 2023. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;The Author(s) 2023 ;ISSN: 2045-2322 ;EISSN: 2045-2322 ;DOI: 10.1038/s41598-023-29065-2 ;PMID: 36725963

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  • Title:
    Tumor organoid biobank-new platform for medical research
  • Author: Xie, Xuexue ; Li, Xinyu ; Song, Wei
  • Subjects: Animals ; Biobanks ; Biological Specimen Banks ; Biomedical Research ; Bladder cancer ; Brain tumors ; Cell culture ; Construction ; Disease Models, Animal ; Drug development ; Drug screening ; Glioma - pathology ; Humans ; Medical research ; Organoids ; Organoids - metabolism ; Pancreas ; Patients ; Precision medicine ; Quality control ; Xenografts
  • Is Part Of: Scientific reports, 2023-02, Vol.13 (1), p.1819-1819, Article 1819
  • Description: Organoids are a new type of 3D model for tumor research, which makes up for the shortcomings of cell lines and xenograft models, and promotes the development of personalized precision medicine. Long-term culture, expansion and storage of organoids provide the necessary conditions for the establishment of biobanks. Biobanks standardize the collection and preservation of normal or pathological specimens, as well as related clinical information. The tumor organoid biobank has a good quality control system, which is conducive to the clinical transformation and large-scale application of tumor organoids, such as disease modeling, new drug development and high-throughput drug screening. This article summarized the common tumor types of patient-derived organoid (PDO) biobanks and the necessary information for biobank construction, such as the number of organoids, morphology, success rate of culture and resuscitation, pathological types. In our results, we found that patient-derived tumor organoid (PDTO) biobanks were being established more and more, with the Netherlands, the United States, and China establishing the most. Biobanks of colorectal, pancreas, breast, glioma, and bladder cancers were established more, which reflected the relative maturity of culture techniques for these tumors. In addition, we provided insights on the precautions and future development direction of PDTO biobank building.
  • Publisher: England: Nature Publishing Group
  • Language: English
  • Identifier: ISSN: 2045-2322
    EISSN: 2045-2322
    DOI: 10.1038/s41598-023-29065-2
    PMID: 36725963
  • Source: MEDLINE
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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