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Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual participant data

The Lancet (British edition), 2012, Vol.379 (9831), p.2053-2062 [Peer Reviewed Journal]

Elsevier Ltd ;2012 Elsevier Ltd ;2015 INIST-CNRS ;Copyright © 2012 Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited Jun 2-Jun 8, 2012 ;ISSN: 0140-6736 ;ISSN: 1474-547X ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(12)60441-3 ;PMID: 22541275 ;CODEN: LANCAO

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Title:
Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual participant data
Author: Lorenz, Matthias W, Dr ; Polak, Joseph F, Prof ; Kavousi, Maryam, MD ; Mathiesen, Ellisiv B, Prof ; Völzke, Henry, Prof ; Tuomainen, Tomi-Pekka, Prof ; Sander, Dirk, Prof ; Plichart, Matthieu, MD ; Catapano, Alberico L, Prof ; Robertson, Christine M, MBChB ; Kiechl, Stefan, Prof ; Rundek, Tatjana, Prof ; Desvarieux, Moïse, MD ; Lind, Lars, Prof ; Schmid, Caroline, PhD ; DasMahapatra, Pronabesh, MD ; Gao, Lu ; Ziegelbauer, Kathrin, MSc ; Bots, Michiel L, Prof ; Thompson, Simon G, Prof
Subjects: Biological and medical sciences ; Cardiac and Cardiovascular Systems ; Cardiovascular disease ; Cardiovascular Diseases - diagnostic imaging ; Cardiovascular Diseases - epidemiology ; Cardiovascular Diseases - pathology ; carotid arteries ; Carotid Intima-Media Thickness ; clinical trials ; death ; Disease Progression ; Follow-Up Studies ; General aspects ; Heart attacks ; Humans ; Internal Medicine ; Kardiologi ; Medical research ; Medical sciences ; Medicin och hälsovetenskap ; meta-analysis ; myocardial infarction ; Myocardial Infarction - diagnostic imaging ; Myocardial Infarction - epidemiology ; Myocardial Infarction - pathology ; Prognosis ; regression analysis ; risk ; Risk Assessment - methods ; risk factors ; stroke ; Stroke - diagnostic imaging ; Stroke - epidemiology ; Stroke - pathology ; Studies ; Systematic review ; teams ; ultrasonics
Is Part Of: The Lancet (British edition), 2012, Vol.379 (9831), p.2053-2062
Description: Summary Background Carotid intima-media thickness (cIMT) is related to the risk of cardiovascular events in the general population. An association between changes in cIMT and cardiovascular risk is frequently assumed but has rarely been reported. Our aim was to test this association. Methods We identified general population studies that assessed cIMT at least twice and followed up participants for myocardial infarction, stroke, or death. The study teams collaborated in an individual participant data meta-analysis. Excluding individuals with previous myocardial infarction or stroke, we assessed the association between cIMT progression and the risk of cardiovascular events (myocardial infarction, stroke, vascular death, or a combination of these) for each study with Cox regression. The log hazard ratios (HRs) per SD difference were pooled by random effects meta-analysis. Findings Of 22 eligible studies, 16 with 36 984 participants were included. During a mean follow-up of 7·0 years, 1519 myocardial infarctions, 1339 strokes, and 2028 combined endpoints (myocardial infarction, stroke, vascular death) occurred. Yearly cIMT progression was derived from two ultrasound visits 2–7 years (median 4 years) apart. For mean common carotid artery intima-media thickness progression, the overall HR of the combined endpoint was 0·97 (95% CI 0·94–1·00) when adjusted for age, sex, and mean common carotid artery intima-media thickness, and 0·98 (0·95–1·01) when also adjusted for vascular risk factors. Although we detected no associations with cIMT progression in sensitivity analyses, the mean cIMT of the two ultrasound scans was positively and robustly associated with cardiovascular risk (HR for the combined endpoint 1·16, 95% CI 1·10–1·22, adjusted for age, sex, mean common carotid artery intima-media thickness progression, and vascular risk factors). In three studies including 3439 participants who had four ultrasound scans, cIMT progression did not correlate between occassions (reproducibility correlations between r =−0·06 and r =−0·02). Interpretation The association between cIMT progression assessed from two ultrasound scans and cardiovascular risk in the general population remains unproven. No conclusion can be derived for the use of cIMT progression as a surrogate in clinical trials. Funding Deutsche Forschungsgemeinschaft.
Publisher: Kidlington: Elsevier Ltd
Language: English
Identifier: ISSN: 0140-6736
ISSN: 1474-547X
EISSN: 1474-547X
DOI: 10.1016/S0140-6736(12)60441-3
PMID: 22541275
CODEN: LANCAO
Source: ProQuest One Psychology
MEDLINE
SWEPUB Freely available online
ProQuest Central

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Carotid intima-media thickness progression to predict cardiovascular events in the general population (the PROG-IMT collaborative project): a meta-analysis of individual participant data

Elsevier Ltd ;2012 Elsevier Ltd ;2015 INIST-CNRS ;Copyright © 2012 Elsevier Ltd. All rights reserved. ;Copyright Elsevier Limited Jun 2-Jun 8, 2012 ;ISSN: 0140-6736 ;ISSN: 1474-547X ;EISSN: 1474-547X ;DOI: 10.1016/S0140-6736(12)60441-3 ;PMID: 22541275 ;CODEN: LANCAO

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