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Effects of Elevating Colonic Propionate on Liver Fat Content in Adults with Non‐Alcoholic Fatty Liver Disease

The FASEB journal, 2015-04, Vol.29 (S1) [Peer Reviewed Journal]

ISSN: 0892-6638 ;EISSN: 1530-6860 ;DOI: 10.1096/fasebj.29.1_supplement.385.2

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  • Title:
    Effects of Elevating Colonic Propionate on Liver Fat Content in Adults with Non‐Alcoholic Fatty Liver Disease
  • Author: Chambers, Edward ; Viardot, Alexander ; Psichas, Arianna ; Morrison, Douglas ; Murphy, Kevin ; Zac‐Varghese, Sagen ; Preston, Tom ; Tedford, Catriona ; Bell, Jimmy ; Thomas, Louise ; Dhillo, Waljit ; Bloom, Stephen ; Frost, Gary
  • Is Part Of: The FASEB journal, 2015-04, Vol.29 (S1)
  • Description: Abstract only Non‐alcoholic fatty liver disease (NAFLD) is reported in 20% of adults worldwide, a condition associated with an increased risk of developing type 2 diabetes. Positive physiological effects have been linked with the production of short chain fatty acids (SCFA) by colonic fermentation of dietary fiber, including reductions in hepatic fat content. We have developed a novel inulin‐propionate ester (IPE), whereby the SCFA propionate is bound to the dietary fiber inulin. The bound propionate is only released through fermentation in the colon and we hypothesized that long term elevations in colonic propionate production would reduce liver fat in adults with NAFLD. Sixteen participants (40‐65 years) were recruited and intrahepatocellular lipid (IHCL) was determined using 1 H‐MRS. All participants were identified as having NAFLD on the basis of a liver fat content >5%. Participants were provided with either 10 g/day IPE ( n =11) or 10 g/day inulin control ( n =5) to add to their normal diet for a 24 week period. In the IPE group a significant reduction in IHCL content post‐intervention was observed (22.1±9.6% to 15.9±7.1%; P=0.038). This effect was not found in the inulin control group (19.1±6.2% to 18.7±4.2%; P=0.576). Targeting increased colonic propionate levels may offer a public health solution to the increased prevalence of NAFLD and warrants further investigation.
  • Language: English
  • Identifier: ISSN: 0892-6638
    EISSN: 1530-6860
    DOI: 10.1096/fasebj.29.1_supplement.385.2
  • Source: Alma/SFX Local Collection
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