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Recent advances in de novo protein design: Principles, methods, and applications

The Journal of biological chemistry, 2021-01, Vol.296, p.100558-100558, Article 100558 [Peer Reviewed Journal]

2021 The Authors ;Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. ;2021 The Authors 2021 ;ISSN: 0021-9258 ;EISSN: 1083-351X ;DOI: 10.1016/j.jbc.2021.100558 ;PMID: 33744284

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  • Title:
    Recent advances in de novo protein design: Principles, methods, and applications
  • Author: Pan, Xingjie ; Kortemme, Tanja
  • Subjects: biophysics ; computational protein design ; de novo protein design ; JBC Reviews ; PDB ; protein structure ; Rosetta
  • Is Part Of: The Journal of biological chemistry, 2021-01, Vol.296, p.100558-100558, Article 100558
  • Description: The computational de novo protein design is increasingly applied to address a number of key challenges in biomedicine and biological engineering. Successes in expanding applications are driven by advances in design principles and methods over several decades. Here, we review recent innovations in major aspects of the de novo protein design and include how these advances were informed by principles of protein architecture and interactions derived from the wealth of structures in the Protein Data Bank. We describe developments in de novo generation of designable backbone structures, optimization of sequences, design scoring functions, and the design of the function. The advances not only highlight design goals reachable now but also point to the challenges and opportunities for the future of the field.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 0021-9258
    EISSN: 1083-351X
    DOI: 10.1016/j.jbc.2021.100558
    PMID: 33744284
  • Source: PubMed Central
    Alma/SFX Local Collection
    DOAJ Directory of Open Access Journals
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