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0085 EFFECT OF SLEEP FRAGMENTATION ON THE MICROBIOME-GUT-BRAIN AXIS

Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A32-A33 [Peer Reviewed Journal]

Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2017 ;Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com ;ISSN: 0161-8105 ;EISSN: 1550-9109 ;DOI: 10.1093/sleepj/zsx050.084

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  • Title:
    0085 EFFECT OF SLEEP FRAGMENTATION ON THE MICROBIOME-GUT-BRAIN AXIS
  • Author: Wellman, LL ; Oldfield, EC ; Shams, R ; Copare, JL ; Ware, JC ; Johnson, DA ; Lundberg, PS ; Ciavarra, RP ; Sanford, LD
  • Subjects: Microbiota ; Sleep
  • Is Part Of: Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A32-A33
  • Description: Abstract Introduction: Bi-directional interactions between the gut microbiota, immune system, and brain (microbiota-gut-brain (M-G-B) axis) are thought to be critical mediators of health and disease. Here, we assessed the effects of sleep fragmentation (SF) on the M-G-B axis. Methods: Mice (4 to 5 per cage) were housed in devices (Lafayette Instruments, Sleep Fragmentation Chamber (SFC), model 80391) that induce SF via mechanical stimulation. The SFCs were set for 2-min intervals for the entire light period (SF) or for the entire dark period (DD, dark disturbances). Home cage (HC) controls were undisturbed. After 10 days, fecal samples were collected at light onset, midday, light-offset, and midnight. Subsequently, the mice were randomized across groups and allowed 20 days of recovery followed by 10 additional days of SF or DD. Fecal samples were subjected to Next-Gen sequencing to assess effects on the microbiota, and the mesenteric lymph nodes (MLNs) and cortex were analyzed using inflammatory cytokine arrays (SABiosciences, PAMM-0011). Results: SF and DD produced significant alterations in the microbiota compared to HC. DD could have a greater impact than SF on some organisms. However, SF had a marked impact on both the peripheral (mucosal) and central immune systems whereas DD was similar to HC. SF produced marked suppression in MLNS of chemokines that regulate inflammation (CCL3, CCL4 and their receptor CCR5) and maintain the immune mucosal barrier (Cxcl13) that prevents bacterial translocation at the same time that cortical cytokines (IL-33) indicated neuroinflammation. Conclusion: These data demonstrate that SF can alter the microbiome and suggest that it may lead to persistent, low-grade brain inflammation at the same time that mucosal immunity is suppressed. The combination of effects of SF on the microbiome and mucosal and central immune systems may have relevance for the role the M-G-B axis plays in mediating health. Support (If Any):
  • Publisher: US: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0161-8105
    EISSN: 1550-9109
    DOI: 10.1093/sleepj/zsx050.084
  • Source: ProQuest One Psychology
    AUTh Library subscriptions: ProQuest Central
    Alma/SFX Local Collection
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