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0090 A MOUSE MODEL OF SLEEP APNEA REVEALS A KEY ROLE FOR LEPTIN IN THE PATHOGENESIS OF DISORDERED BREATHING

Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A34-A34 [Peer Reviewed Journal]

Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com 2017 ;Sleep Research Society 2017. Published by Oxford University Press [on behalf of the Sleep Research Society]. All rights reserved. For permissions, please email: journals.permissions@oup.com ;ISSN: 0161-8105 ;EISSN: 1550-9109 ;DOI: 10.1093/sleepj/zsx050.089

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  • Title:
    0090 A MOUSE MODEL OF SLEEP APNEA REVEALS A KEY ROLE FOR LEPTIN IN THE PATHOGENESIS OF DISORDERED BREATHING
  • Author: Arble, D ; Flak, J ; Myers, M ; Sandoval, D ; Seeley, R
  • Subjects: Hormones ; Pathogenesis ; Respiration ; Sleep apnea ; Sleep disorders
  • Is Part Of: Sleep (New York, N.Y.), 2017-04, Vol.40 (suppl_1), p.A34-A34
  • Description: Abstract Introduction: Sleep apnea is highly correlated with obesity and neck circumference. This observation has led many to conclude that the physical weight of fat around the airway leads to restriction and apnea. However, recent evidence implicates obesity-related physiology, including the role of leptin, in the pathogenesis of sleep apnea. Here we determine how leptin signaling within the periaqueductal gray (PAG) affects baseline ventilation and the ventilatory response to hypercapnia (HCVR) using a mouse model. Methods: To ablate leptin receptors specifically within the PAG, we used a local injection of an adeno-associated virus that drives cre-expression in LepR floxed mice. To drive leptin receptor (LepR) neurons within the PAG, we used LepRcre/L10 mice locally injected with a cre-inducible DREADD hM3dq virus. Results: Ablating leptin receptors within the PAG leads to tachypnea, as demonstrated by an increased breathing frequency and shorted expiration times. Similarly, driving LepR neurons within the PAG leads to tachypnea but also results in a significant decrease in HCVR. Conclusion: Using this model, we find that leptin signaling within the PAG can alter respiration and respiratory drive. Taken together with our previous findings, these data suggest a neuronal component to disordered breathing independent of physical body weight. Support (If Any): NIH-NIDDK: DK082480-01 (D.Sandoval) and DK093848-01 (R.Seeley).
  • Publisher: US: Oxford University Press
  • Language: English
  • Identifier: ISSN: 0161-8105
    EISSN: 1550-9109
    DOI: 10.1093/sleepj/zsx050.089
  • Source: ProQuest One Psychology
    AUTh Library subscriptions: ProQuest Central
    Alma/SFX Local Collection
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