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Phytolacca dodecandra (Phytolaccaceae) Root Extract Exhibits Antioxidant and Hepatoprotective Activities in Mice with CCl4-Induced Acute Liver Damage

Clinical and experimental gastroenterology, 2021-01, Vol.14, p.59-70 [Peer Reviewed Journal]

2021. This work is licensed under https://creativecommons.org/licenses/by-nc/3.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2021 Meharie and Tunta. 2021 Meharie and Tunta. ;ISSN: 1178-7023 ;EISSN: 1178-7023 ;DOI: 10.2147/CEG.S290859 ;PMID: 33603434

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  • Title:
    Phytolacca dodecandra (Phytolaccaceae) Root Extract Exhibits Antioxidant and Hepatoprotective Activities in Mice with CCl4-Induced Acute Liver Damage
  • Author: Meharie, Birhanu Geta ; Tunta, Tewodros Agedew
  • Subjects: Animals ; Antioxidants ; ccl4 ; dpph ; Drinking water ; Drug dosages ; Experiments ; hepatoprotective ; Laboratories ; Liver ; mice ; Original Research ; Phytochemicals ; phytolacca dodecandra ; Potassium ; Reagents ; Solvents ; tbars
  • Is Part Of: Clinical and experimental gastroenterology, 2021-01, Vol.14, p.59-70
  • Description: Background: The liver is a hub of metabolism and detoxification of substances. Since many redox reactions take place in the liver, it is prone to oxidative damage. Unlike conventional agents, botanicals act through several mechanisms in preventing oxidative damage. Among these Phytolacca dodecandra is the most commonly used agent in Ethiopian folk medicine. Objective: To evaluate antioxidant and hepatoprotective activities of the 80% methanol extract of P. dodecandra root. Methods: Male mice were divided into six groups and treated accordingly. Negative control was given 2% Tween 80, toxicant control administered with carbon tetrachloride (CCl4), positive control treated with silymarin 100 mg/kg, and test groups were treated with 100, 200, and 400 mg/kg of the extract. Then, serum levels of alkaline phosphatase (ALP), alanine aminotransferase (ALT), aspartate aminotransferase (AST), gamma-glutamyl transferase (GGT), lactate dehydrogenase (LDH), total cholesterol (TC), triglyceride (TG), low-density lipoprotein (LDL) cholesterol, high-density lipoprotein (HDL) cholesterol, albumin, total protein, and bilirubin were determined. Determination of the change in body weight and liver weight, histopathologic examination of the liver, and in vitro and in vivo antioxidant assays were also carried out. Results: The levels of ALP, ALT, AST, GGT, LDH, and bilirubin were significantly reduced, while albumin and total protein were significantly increased after treatment with P. dodecandra root extract at the doses of 200 and 400 mg/kg in CCl4 intoxicated mice. Cholesterol metabolism and lipoprotein synthesis capabilities of the liver of mice were also returned to normal in the two doses. Besides, the 200 and 400 mg/kg doses were able to return the normal architecture and morphology of hepatocytes. Furthermore, the plant extract was found to scavenge free radicals in vitro and inhibit lipid peroxidation in vivo. Conclusion: The results suggest that the 80% methanol extract of P. dodecandra root can be used for the management of liver disease.
  • Publisher: Macclesfield: Taylor & Francis Ltd
  • Language: English
  • Identifier: ISSN: 1178-7023
    EISSN: 1178-7023
    DOI: 10.2147/CEG.S290859
    PMID: 33603434
  • Source: GFMER Free Medical Journals
    PubMed Central
    ROAD: Directory of Open Access Scholarly Resources
    ProQuest Central
    DOAJ Directory of Open Access Journals
    Dove Press Free
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