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Medical Treatment Strategies for Hypertrophic Cardiomyopathy

The American journal of cardiology, 2024-02, Vol.212, p.S33-S41 [Peer Reviewed Journal]

2023 The Author(s) ;Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. ;2023. The Author(s) ;ISSN: 0002-9149 ;EISSN: 1879-1913 ;DOI: 10.1016/j.amjcard.2023.10.074 ;PMID: 38368034

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Title:
Medical Treatment Strategies for Hypertrophic Cardiomyopathy
Author: Hutt, Erika ; Desai, Milind Y.
Subjects: Angina pectoris ; Antiarrhythmics ; Beta blockers ; Cardiac arrhythmia ; cardiac myosin inhibitor ; Cardiomyopathy ; Cardiomyopathy, Hypertrophic - diagnosis ; Cardiovascular diseases ; Clinical trials ; Congestive heart failure ; Death ; Death, Sudden, Cardiac - etiology ; Death, Sudden, Cardiac - prevention & control ; Drug dosages ; Drug therapy ; Dyspnea ; Genetic Counseling ; Genetic screening ; Health services ; Heart diseases ; Heart Failure - genetics ; Heart rate ; Heart transplantation ; Heart transplants ; Humans ; hypertrophic cardiomyopathy ; Ischemia ; medical therapies ; Medical treatment ; Mortality ; Multicenter Studies as Topic ; Myosin ; Patients ; Risk management ; Signs and symptoms
Is Part Of: The American journal of cardiology, 2024-02, Vol.212, p.S33-S41
Description: Hypertrophic cardiomyopathy (HCM) is a heterogeneous genetic heart disease inherited in an autosomal dominant pattern with an estimated prevalence of 0.6% in the general population. Clinical manifestations of HCM vary considerably, with symptoms ranging from none or mild exercise intolerance to severe lifestyle-limiting symptoms, advanced heart failure, and sudden cardiac death. Current management options for HCM include lifestyle modifications, familial screening with genetic counseling, pharmacotherapy for symptom control, sudden cardiac death risk stratification with or without defibrillator implantation, septal reduction therapy, and, in some cases, heart transplantation. Only recently have strongly targeted medical therapies for HCM, such as myosin inhibitors, been studied in multicenter randomized controlled trials. In this report, we review the currently available medical treatments for HCM and the future directions of HCM pharmacotherapy, and we highlight important unmet needs in this population.
Publisher: United States: Elsevier Inc
Language: English
Identifier: ISSN: 0002-9149
EISSN: 1879-1913
DOI: 10.1016/j.amjcard.2023.10.074
PMID: 38368034
Source: AUTh Library subscriptions: ProQuest Central
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Medical Treatment Strategies for Hypertrophic Cardiomyopathy

2023 The Author(s) ;Copyright © 2023 The Author(s). Published by Elsevier Inc. All rights reserved. ;2023. The Author(s) ;ISSN: 0002-9149 ;EISSN: 1879-1913 ;DOI: 10.1016/j.amjcard.2023.10.074 ;PMID: 38368034

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