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Neurovascular Unit: A critical role in ischemic stroke

CNS neuroscience & therapeutics, 2021-01, Vol.27 (1), p.7-16 [Peer Reviewed Journal]

2021 The Authors. Published by John Wiley & Sons Ltd. ;2021 The Authors. CNS Neuroscience & Therapeutics Published by John Wiley & Sons Ltd. ;2021. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1755-5930 ;EISSN: 1755-5949 ;DOI: 10.1111/cns.13561 ;PMID: 33389780

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  • Title:
    Neurovascular Unit: A critical role in ischemic stroke
  • Author: Wang, Liyun ; Xiong, Xiaoxing ; Zhang, Luyuan ; Shen, Jian
  • Subjects: Blood vessels ; Blood-brain barrier ; Brain damage ; Cerebrovascular diseases ; Edema ; Growth factors ; Immune response ; Inflammation ; Ischemia ; Medical prognosis ; MicroRNAs ; Neurons ; Neurovascular unit ; Permeability ; Proteins ; Review ; Smooth muscle ; Stroke ; Therapy
  • Is Part Of: CNS neuroscience & therapeutics, 2021-01, Vol.27 (1), p.7-16
  • Description: Ischemic stroke (IS), a common cerebrovascular disease, results from a sudden blockage of a blood vessel in the brain, thereby restricting blood supply to the area in question, and making a significantly negative impact on human health. Unfortunately, current treatments, that are mainly based on a recanalization of occluded blood vessels, are insufficient or inaccessible to many stroke patients. Recently, the profound influence of the neurovascular unit (NVU) on recanalization and the prognosis of IS have become better understood; in‐depth studies of the NVU have also provided novel approaches for IS treatment. In this article, we review the intimate connections between the changes in the NVU and IS outcomes, and discuss possible new management strategies having practical significance to IS. We discuss the concept of the NVU, as well as its roles in IS blood‐brain barrier regulation, cell preservation, inflammatory immune response, and neurovascular repair. Besides, we also summarize the influence of noncoding RNAs in NVU, and IS therapies targeting the NVU. We conclude that both the pathophysiological and neurovascular repair processes of IS are strongly associated with the homeostatic state of the NVU and that further research into therapies directed at the NVU could expand the range of treatments available for IS. Neurovascular unit plays a leading role in the pathophysiological process of ischemic stroke. Both cell‐based therapies and drugs targeting the neurovascular unit can fight against ischemic stroke. The entire multiple cells’ interaction framework of the neurovascular unit are worth to further study to explore the therapeutic potential of the neurovascular unit in clinical.
  • Publisher: England: John Wiley & Sons, Inc
  • Language: English
  • Identifier: ISSN: 1755-5930
    EISSN: 1755-5949
    DOI: 10.1111/cns.13561
    PMID: 33389780
  • Source: Journals@Ovid Open Access Journal Collection Rolling
    PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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