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Fibroblast growth factors in the management of spinal cord injury

Journal of cellular and molecular medicine, 2018-01, Vol.22 (1), p.25-37 [Peer Reviewed Journal]

2017 The Authors. Journal of Cellular and Molecular Medicine published by John Wiley & Sons Ltd and Foundation for Cellular and Molecular Medicine. ;2018. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;ISSN: 1582-1838 ;EISSN: 1582-4934 ;DOI: 10.1111/jcmm.13353 ;PMID: 29063730

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  • Title:
    Fibroblast growth factors in the management of spinal cord injury
  • Author: Zhou, Yulong ; Wang, Zhouguang ; Li, Jiawei ; Li, Xiaokun ; Xiao, Jian
  • Subjects: Animal models ; Cell death ; Central nervous system ; clinical trials ; combination therapy ; Economic conditions ; Edema ; Fibroblast growth factor ; Fibroblasts ; Free radicals ; Growth factors ; Hemorrhage ; Homeostasis ; Inflammation ; Inflammatory response ; Ischemia ; recovery ; Recovery of function ; Review ; Reviews ; Signal transduction ; Spinal cord ; Spinal cord injuries ; Spinal cord injury ; Spinal plasticity ; Transplantation
  • Is Part Of: Journal of cellular and molecular medicine, 2018-01, Vol.22 (1), p.25-37
  • Description: Spinal cord injury (SCI) possesses a significant health and economic burden worldwide. Traumatic SCI is a devastating condition that evolves through two successive stages. Throughout each of these stages, disturbances in ionic homeostasis, local oedema, ischaemia, focal haemorrhage, free radicals stress and inflammatory response were observed. Although there are no fully restorative cures available for SCI patients, various molecular, cellular and rehabilitative therapies, such as limiting local inflammation, preventing secondary cell death and enhancing the plasticity of local circuits in the spinal cord, were described. Current preclinical studies have showed that fibroblast growth factors (FGFs) alone or combination therapies utilizing cell transplantation and biomaterial scaffolds are proven effective for treating SCI in animal models. More importantly, some studies further demonstrated a paucity of clinical transfer usage to promote functional recovery of numerous patients with SCI. In this review, we focus on the therapeutic capacity and pitfalls of the FGF family and its clinical application for treating SCI, including the signalling component of the FGF pathway and the role in the central nervous system, the pathophysiology of SCI and the targets for FGF treatment. We also discuss the challenges and potential for the clinical translation of FGF‐based approaches into treatments for SCI.
  • Publisher: England: John Wiley & Sons, Inc
  • Language: English
  • Identifier: ISSN: 1582-1838
    EISSN: 1582-4934
    DOI: 10.1111/jcmm.13353
    PMID: 29063730
  • Source: Open Access: DOAJ Directory of Open Access Journals
    Open Access: PubMed Central
    Open Access: Wiley Blackwell Open Access Journals
    Journals@Ovid Open Access Journal Collection Rolling
    AUTh Library subscriptions: ProQuest Central
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