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Androgen receptor signaling in prostate cancer development and progression

Journal of carcinogenesis, 2011, Vol.10 (1), p.20-20 [Peer Reviewed Journal]

2011 Lonergan. 2011 ;ISSN: 1477-3163 ;EISSN: 1477-3163 ;DOI: 10.4103/1477-3163.83937 ;PMID: 21886458

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  • Title:
    Androgen receptor signaling in prostate cancer development and progression
  • Author: Lonergan, Peter E ; Tindall, Donald J
  • Subjects: Review
  • Is Part Of: Journal of carcinogenesis, 2011, Vol.10 (1), p.20-20
  • Description: The androgen receptor (AR) signaling axis plays a critical role in the development, function and homeostasis of the prostate. The classical action of AR is to regulate gene transcriptional processes via AR nuclear translocation, binding to androgen response elements on target genes and recruitment of, or crosstalk with, transcription factors. Prostate cancer initiation and progression is also uniquely dependent on AR. Androgen deprivation therapy remains the standard of care for treatment of advanced prostate cancer. Despite an initial favorable response, almost all patients invariably progress to a more aggressive, castrate-resistant phenotype. Considerable evidence now supports the concept that development of castrate-resistant prostate cancer (CRPC) is causally related to continued transactivation of AR. Understanding the critical events and complexities of AR signaling in the progression to CRPC is essential in developing successful future therapies. This review provides a synopsis of AR structure and signaling in prostate cancer progression, with a special focus on recent findings on the role of AR in CRPC. Clinical implications of these findings and potential directions for future research are also outlined.
  • Publisher: India: Medknow Publications
  • Language: English
  • Identifier: ISSN: 1477-3163
    EISSN: 1477-3163
    DOI: 10.4103/1477-3163.83937
    PMID: 21886458
  • Source: Open Access: PubMed Central
    Geneva Foundation Free Medical Journals at publisher websites
    ROAD: Directory of Open Access Scholarly Resources
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