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Pregnancy complications and cardiovascular disease death: 50-year follow-up of the Child Health and Development Studies pregnancy cohort

Circulation (New York, N.Y.), 2015-09, Vol.132 (13), p.1234-1242 [Tạp chí có phản biện]

2015 American Heart Association, Inc. ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.113.003901 ;PMID: 26391409

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Nhan đề:
Pregnancy complications and cardiovascular disease death: 50-year follow-up of the Child Health and Development Studies pregnancy cohort
Tác giả: Cirillo, Piera M ; Cohn, Barbara A
Chủ đề: Adult ; Anemia - blood ; Anemia - epidemiology ; California - epidemiology ; Cardiovascular Diseases - mortality ; Cause of Death ; Female ; Follow-Up Studies ; Forecasting ; Glycosuria - epidemiology ; Hemoglobins - analysis ; Humans ; Hypertension - epidemiology ; Hypertension, Pregnancy-Induced - epidemiology ; Infant, Newborn ; Infant, Premature ; Infant, Small for Gestational Age ; Obstetric Labor, Premature - epidemiology ; Pre-Eclampsia - epidemiology ; Pregnancy ; Pregnancy Complications - blood ; Pregnancy Complications - epidemiology ; Prognosis ; Proportional Hazards Models ; Risk Factors ; Young Adult
Là 1 phần của: Circulation (New York, N.Y.), 2015-09, Vol.132 (13), p.1234-1242
Mô tả: Few studies have investigated the combination of pregnancy complications that predict risk for cardiovascular disease (CVD) death and how risk changes with age. This report presents a comprehensive investigation of the relation of the occurrence of multiple pregnancy complications to CVD death over 5 decades in a large pregnancy cohort. We examined pregnancy events (1959-1967) and CVD death through 2011 in 14 062 women from the Child Health and Development Studies. CVD death was determined by linkage to California Vital Statistics and National Death Index. Women were a median age of 26 years at enrollment and 66 years in 2011. Preexisting hypertension (hazard ratio, 3.5; 95% confidence interval, 2.4-5.1); glycosuria (hazard ratio, 4.2; confidence interval, 1.3-13.1); late-onset preeclampsia (after week 34, hazard ratio, 2.0; confidence interval, 1.2-3.5); and hemoglobin decline over the second and third trimesters (hazard ratio, 1.7; confidence interval, 1.2-2.7) predicted CVD death. Delivery of a small-for-gestation or preterm infant and early-onset preeclampsia (by week 34) significantly predicted premature CVD death (P<0.05 for age dependence). Preterm birth combined with hemorrhage, gestational hypertension, or preexisting hypertension identified women with a 4- to 7-fold increased risk of CVD death. Preeclampsia in combination with preexisting hypertension conferred a significant nearly 6-fold risk in comparison with a 4-fold risk for preexisting hypertension alone. We observed combinations of pregnancy complications that predict high risk of death and 2 new risk markers, glycosuria and hemoglobin decline. Obstetricians serve as primary care physicians for many young women and can readily use these complications to identify high-risk women to implement early prevention.
Nơi xuất bản: United States
Ngôn ngữ: English
Số nhận dạng: ISSN: 0009-7322
EISSN: 1524-4539
DOI: 10.1161/CIRCULATIONAHA.113.003901
PMID: 26391409
Nguồn: Geneva Foundation Free Medical Journals at publisher websites
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Pregnancy complications and cardiovascular disease death: 50-year follow-up of the Child Health and Development Studies pregnancy cohort

2015 American Heart Association, Inc. ;ISSN: 0009-7322 ;EISSN: 1524-4539 ;DOI: 10.1161/CIRCULATIONAHA.113.003901 ;PMID: 26391409

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