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The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

International journal of molecular sciences, 2019-07, Vol.20 (13), p.3328 [Peer Reviewed Journal]

2019. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2019 by the authors. 2019 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms20133328 ;PMID: 31284572

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Title:
The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation
Author: Kelley, Nathan ; Jeltema, Devon ; Duan, Yanhui ; He, Yuan
Subjects: Animals ; Apoptosis ; Caspase-1 ; Caspase-11 ; Cytokines ; Efflux ; Humans ; IL-1β ; Immune system ; Inflammasomes ; Inflammasomes - metabolism ; Interleukin 18 ; Ionic flux ; Kinases ; Ligands ; Lysosomal damage ; Mitochondria - pathology ; Mitochondrial DNA ; Mitochondrial dysfunction ; Models, Biological ; MyD88 protein ; NF-κB protein ; NLR Family, Pyrin Domain-Containing 3 Protein - metabolism ; NLRP3 inflammasome ; NLRP3 regulators ; Pathogens ; Phosphorylation ; Post-translational modification ; Priming ; Protein Processing, Post-Translational ; Proteins ; Reactive Oxygen Species - metabolism ; Review ; ROS ; Signal transduction ; Signaling ; Transcription activation ; Viral infections
Is Part Of: International journal of molecular sciences, 2019-07, Vol.20 (13), p.3328
Description: The NLRP3 inflammasome is a critical component of the innate immune system that mediates caspase-1 activation and the secretion of proinflammatory cytokines IL-1β/IL-18 in response to microbial infection and cellular damage. However, the aberrant activation of the NLRP3 inflammasome has been linked with several inflammatory disorders, which include cryopyrin-associated periodic syndromes, Alzheimer's disease, diabetes, and atherosclerosis. The NLRP3 inflammasome is activated by diverse stimuli, and multiple molecular and cellular events, including ionic flux, mitochondrial dysfunction, and the production of reactive oxygen species, and lysosomal damage have been shown to trigger its activation. How NLRP3 responds to those signaling events and initiates the assembly of the NLRP3 inflammasome is not fully understood. In this review, we summarize our current understanding of the mechanisms of NLRP3 inflammasome activation by multiple signaling events, and its regulation by post-translational modifications and interacting partners of NLRP3.
Publisher: Switzerland: MDPI AG
Language: English
Identifier: ISSN: 1422-0067
ISSN: 1661-6596
EISSN: 1422-0067
DOI: 10.3390/ijms20133328
PMID: 31284572
Source: MEDLINE
PubMed Central
ProQuest Central
DOAJ Directory of Open Access Journals

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The NLRP3 Inflammasome: An Overview of Mechanisms of Activation and Regulation

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