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Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System

International journal of molecular sciences, 2018-03, Vol.19 (3), p.833 [Peer Reviewed Journal]

2018. This work is licensed under https://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. ;2018 by the authors. 2018 ;ISSN: 1422-0067 ;ISSN: 1661-6596 ;EISSN: 1422-0067 ;DOI: 10.3390/ijms19030833 ;PMID: 29533978

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  • Title:
    Cannabinoid Receptors and the Endocannabinoid System: Signaling and Function in the Central Nervous System
  • Author: Zou, Shenglong ; Kumar, Ujendra
  • Subjects: Biological effects ; cannabinoid ; Cannabinoid CB1 receptors ; Cannabis ; Central nervous system ; endocannabinoid ; Endocannabinoid system ; G protein-coupled receptors ; Marijuana ; Nervous system ; Neurological diseases ; Proteins ; receptor ; Receptor mechanisms ; Review ; Signal transduction ; Signaling
  • Is Part Of: International journal of molecular sciences, 2018-03, Vol.19 (3), p.833
  • Description: The biological effects of cannabinoids, the major constituents of the ancient medicinal plant (marijuana) are mediated by two members of the G-protein coupled receptor family, cannabinoid receptors 1 (CB1R) and 2. The CB1R is the prominent subtype in the central nervous system (CNS) and has drawn great attention as a potential therapeutic avenue in several pathological conditions, including neuropsychological disorders and neurodegenerative diseases. Furthermore, cannabinoids also modulate signal transduction pathways and exert profound effects at peripheral sites. Although cannabinoids have therapeutic potential, their psychoactive effects have largely limited their use in clinical practice. In this review, we briefly summarized our knowledge of cannabinoids and the endocannabinoid system, focusing on the CB1R and the CNS, with emphasis on recent breakthroughs in the field. We aim to define several potential roles of cannabinoid receptors in the modulation of signaling pathways and in association with several pathophysiological conditions. We believe that the therapeutic significance of cannabinoids is masked by the adverse effects and here alternative strategies are discussed to take therapeutic advantage of cannabinoids.
  • Publisher: Switzerland: MDPI AG
  • Language: English
  • Identifier: ISSN: 1422-0067
    ISSN: 1661-6596
    EISSN: 1422-0067
    DOI: 10.3390/ijms19030833
    PMID: 29533978
  • Source: PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals

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