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Polymorphism of MUC1 Gene in Vietnamese Gastric Cancer Patients: A Multicenter Case-Control Study

Frontiers in oncology, 2021-08, Vol.11, p.694977-694977 [Peer Reviewed Journal]

Copyright © 2021 Nguyen, Dang, Dang, Tran, Vo, Yamaguchi and Ta. ;Copyright © 2021 Nguyen, Dang, Dang, Tran, Vo, Yamaguchi and Ta 2021 Nguyen, Dang, Dang, Tran, Vo, Yamaguchi and Ta ;ISSN: 2234-943X ;EISSN: 2234-943X ;DOI: 10.3389/fonc.2021.694977 ;PMID: 34532288

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  • Title:
    Polymorphism of MUC1 Gene in Vietnamese Gastric Cancer Patients: A Multicenter Case-Control Study
  • Author: Nguyen, Ngoc-Lan Thi ; Dang, Ngoc-Dzung Thi ; Dang, Quang-Huy ; Tran, Van-Chuc ; Vo, Hoang-Long ; Yamaguchi, Masamitsu ; Ta, Thanh-Van
  • Subjects: gastric cancer ; MUC1 gene ; Mucin 1 gene ; Oncology ; polymorphism ; rs2070803 ; rs4072037
  • Is Part Of: Frontiers in oncology, 2021-08, Vol.11, p.694977-694977
  • Description: A few studies revealed that the polymorphisms of gene have a role and significance as a susceptible factor contributing to gastric cancer. To better understand the roles of two genotype polymorphisms of rs4072037 and rs2070803 in the development of gastric cancer in Vietnamese population, a multicenter, large-sample, case-control study was conducted to investigate the potential association of these single-nucleotide polymorphisms (SNPs) of gene with gastric cancer risk and to evaluate the combination factors in relation with these SNPs. This case-control study included 302 gastric cancer patients and 304 controls at four national medical hospitals between 2016 and 2018. All participants were interviewed for sociodemographic characteristics, smoking and drinking status, and personal and family history of gastric diseases. Genotyping was done using polymerase chain reaction-restriction fragment length polymorphism analysis. The association of SNPs with gastric cancer was explored using logistic regression models. AA genotype for rs4072037 was significantly associated with increased gastric cancer. Those with AA genotype had higher gastric cancer risk than had patients with AG (OR: 2.09, 95% CI: 1.48-2.96) and a combination of AG+GG (OR: 1.85, 95% CI: 1.33-2.56). In rs2070803, GG genotype increased gastric cancer risk when compared with AG (OR: 1.97, 95% CI: 1.39-2.80) and AG+AA (OR: 1.71, 95% CI: 1.23-2.39). AG genotypes in both SNPs decreased gastric cancer risk when compared with homogenous genotype, more specifically AA (OR: 0.51, 95% CI: 0.35-0.72) and GG (OR: 0.58, 95% CI: 0.35-0.97). These genotypes in combination with above-60-year-old age, male gender, alcoholism, and personal history of gastric disease were also significantly elevated risk factors for gastric cancer. rs4072037 and rs2070803 of genes are two genotypic risk factors for gastric cancer. Those in combination with gender, family history, smoking, and drinking habits significantly increase the risk of gastric cancer.
  • Publisher: Switzerland: Frontiers Media S.A
  • Language: English
  • Identifier: ISSN: 2234-943X
    EISSN: 2234-943X
    DOI: 10.3389/fonc.2021.694977
    PMID: 34532288
  • Source: GFMER Free Medical Journals
    PubMed Central
    Alma/SFX Local Collection
    ROAD: Directory of Open Access Scholarly Resources
    DOAJ Directory of Open Access Journals
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