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Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?

Cell, 2008-01, Vol.132 (2), p.171-176 [Peer Reviewed Journal]

2008 Elsevier Inc. ;ISSN: 0092-8674 ;EISSN: 1097-4172 ;DOI: 10.1016/j.cell.2008.01.007 ;PMID: 18243090

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  • Title:
    Mitochondria—A Nexus for Aging, Calorie Restriction, and Sirtuins?
  • Author: Guarente, Leonard
  • Subjects: Aging ; Animals ; Caloric Restriction ; Humans ; Mitochondria - physiology ; Models, Biological ; Sirtuins
  • Is Part Of: Cell, 2008-01, Vol.132 (2), p.171-176
  • Description: Recent studies of calorie restriction in several organisms demonstrate an increase in mitochondrial activity that is associated with the salutary effects of this dietary restriction regimen. In this Essay, I speculate on how an increase in mitochondrial activity might provide benefit and discuss how diet, mitochondria, and sirtuins might interact in a pathway to slow aging and associated diseases.
  • Publisher: United States: Elsevier Inc
  • Language: English
  • Identifier: ISSN: 0092-8674
    EISSN: 1097-4172
    DOI: 10.1016/j.cell.2008.01.007
    PMID: 18243090
  • Source: MEDLINE
    Open Access: Cell Press Free Archives

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