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Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function

Cardiovascular research, 2010-07, Vol.87 (2), p.331-339 [Peer Reviewed Journal]

2015 INIST-CNRS ;Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org. 2010 ;ISSN: 0008-6363 ;EISSN: 1755-3245 ;DOI: 10.1093/cvr/cvq145 ;PMID: 20472566 ;CODEN: CVREAU

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Title:
Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function
Author: Dongaonkar, Ranjeet M. ; Stewart, Randolph H. ; Geissler, Hans J. ; Laine, Glen A.
Subjects: Animals ; Biological and medical sciences ; Body Fluids - metabolism ; Capillary Permeability ; Cardiology. Vascular system ; Coronary Vessels - metabolism ; Coronary Vessels - physiopathology ; Diagnostic Imaging - methods ; Edema, Cardiac - diagnosis ; Edema, Cardiac - metabolism ; Edema, Cardiac - physiopathology ; Hemodynamics ; Humans ; Interstitial compliance ; Lymphatics ; Medical sciences ; Microvessels - metabolism ; Microvessels - physiopathology ; Models, Cardiovascular ; Myocardial Contraction ; Myocardial oedema ; Myocardium - metabolism ; Oedemagenic gain ; Predictive Value of Tests ; Signal Transduction ; Spotlight Reviews ; Ventricular Function
Is Part Of: Cardiovascular research, 2010-07, Vol.87 (2), p.331-339
Description: The heart, perhaps more than any other organ, is exquisitely sensitive to increases in microvascular permeability and the accumulation of myocardial interstitial oedema fluid. Whereas some organs can cope with profound increases in the interstitial fluid volume or oedema formation without a compromise in function, heart function is significantly compromised with only a few percent increase in the interstitial fluid volume. This would be of little consequence if myocardial oedema were an uncommon pathology. On the contrary, myocardial oedema forms in response to many disease states as well as clinical interventions such as cardiopulmonary bypass and cardioplegic arrest common to many cardiothoracic surgical procedures. The heart's inability to function effectively in the presence of myocardial oedema is further confounded by the perplexing fact that the resolution of myocardial oedema does not restore normal cardiac function. We will attempt to provide some insight as to how microvascular permeability and myocardial oedema formation compromise cardiac function and discuss the acute changes that might take place in the myocardium to perpetuate compromised cardiac function following oedema resolution. We will also discuss compensatory changes in the interstitial matrix of the heart in response to chronic myocardial oedema and the role they play to optimize myocardial function during chronic oedemagenic disease.
Publisher: Oxford: Oxford University Press
Language: English
Identifier: ISSN: 0008-6363
EISSN: 1755-3245
DOI: 10.1093/cvr/cvq145
PMID: 20472566
CODEN: CVREAU
Source: GFMER Free Medical Journals
MEDLINE
Alma/SFX Local Collection

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Myocardial microvascular permeability, interstitial oedema, and compromised cardiac function

2015 INIST-CNRS ;Published on behalf of the European Society of Cardiology. All rights reserved. © The Author 2010. For permissions please email: journals.permissions@oxfordjournals.org. 2010 ;ISSN: 0008-6363 ;EISSN: 1755-3245 ;DOI: 10.1093/cvr/cvq145 ;PMID: 20472566 ;CODEN: CVREAU

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