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Comparison of Risk and Age at Diagnosis of Myocardial Infarction, End-Stage Renal Disease, and Non-AIDS-Defining Cancer in HIV-Infected Versus Uninfected Adults

Clinical infectious diseases, 2015-02, Vol.60 (4), p.627-638 [Peer Reviewed Journal]

Copyright © 2015 Oxford University Press on behalf of the Infectious Diseases Society of America ;The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. ;The Author 2014. Published by Oxford University Press on behalf of the Infectious Diseases Society of America. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com. 2014 ;ISSN: 1058-4838 ;EISSN: 1537-6591 ;DOI: 10.1093/cid/ciu869 ;PMID: 25362204

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Title:
Comparison of Risk and Age at Diagnosis of Myocardial Infarction, End-Stage Renal Disease, and Non-AIDS-Defining Cancer in HIV-Infected Versus Uninfected Adults
Author: Althoff, Keri N. ; McGinnis, Kathleen A. ; Wyatt, Christina M. ; Freiberg, Matthew S. ; Gilbert, Cynthia ; Oursler, Krisann K. ; Rimland, David ; Rodriguez-Barradas, Maria C. ; Dubrow, Robert ; Park, Lesley S. ; Skanderson, Melissa ; Shiels, Meredith S. ; Gange, Stephen J. ; Gebo, Kelly A. ; Justice, Amy C.
Subjects: Acquired Immunodeficiency Syndrome - complications ; Adult ; Age ; Aging ; and Commentaries ; Cohort Studies ; Female ; Heart attacks ; HIV ; HIV Infections - complications ; HIV/AIDS ; Human immunodeficiency virus ; Humans ; Kidney diseases ; Kidney Failure, Chronic - diagnosis ; Linear Models ; Male ; Medical diagnosis ; Middle Aged ; Myocardial Infarction - diagnosis ; Neoplasms - diagnosis ; Proportional Hazards Models ; Prospective Studies ; Risk ; Risk factors ; Veterans ; Young Adult
Is Part Of: Clinical infectious diseases, 2015-02, Vol.60 (4), p.627-638
Description: Background. Although it has been shown that human immunodeficiency virus (HIV)-infected adults are at greater risk for aging-associated events, it remains unclear as to whether these events happen at similar, or younger ages, in HIV-infected compared with uninfected adults. The objective of this study was to compare the median age at, and risk of, incident diagnosis of 3 age-associated diseases in HIV-infected and demographically similar uninfected adults. Methods. The study was nested in the clinical prospective Veterans Aging Cohort Study of HIV-infected and demographically matched uninfected veterans, from 1 April 2003 to 31 December 2010. The outcomes were validated diagnoses of myocardial infarction (MI), end-stage renal disease (ESRD), and non-AIDS-defining cancer (NADC). Differences in mean age at, and risk of, diagnosis by HIV status were estimated using multivariate linear regression models and Cox proportional hazards models, respectively. Results. A total of 98 687 (31% HIV-infected and 69% uninfected) adults contributed >450 000 person-years and 689 MI, 1135 ESRD, and 4179 NADC incident diagnoses. Mean age at MI (adjusted mean difference, –0.11; 95% confidence interval [CI], –.59 to .37 years) and NADC (adjusted mean difference, –0.10 [95% CI, –.30 to .10] years) did not differ by HIV status. HIV-infected adults were diagnosed with ESRD at an average age of 5.5 months younger than uninfected adults (adjusted mean difference, –0.46 [95% CI, –.86 to –.07] years). HIV-infected adults had a greater risk of all 3 outcomes compared with uninfected adults after accounting for important confounders. Conclusions. HIV-infected adults had a higher risk of these age-associated events, but they occurred at similar ages than those without HIV.
Publisher: United States: Oxford University Press
Language: English
Identifier: ISSN: 1058-4838
EISSN: 1537-6591
DOI: 10.1093/cid/ciu869
PMID: 25362204
Source: MEDLINE
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Comparison of Risk and Age at Diagnosis of Myocardial Infarction, End-Stage Renal Disease, and Non-AIDS-Defining Cancer in HIV-Infected Versus Uninfected Adults

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