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Concepts of extracellular matrix remodelling in tumour progression and metastasis

Nature communications, 2020-10, Vol.11 (1), p.1-19, Article 5120 [Peer Reviewed Journal]

The Author(s) 2020 ;ISSN: 2041-1723 ;EISSN: 2041-1723 ;DOI: 10.1038/s41467-020-18794-x ;PMID: 33037194

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  • Title:
    Concepts of extracellular matrix remodelling in tumour progression and metastasis
  • Author: Winkler, Juliane ; Abisoye-Ogunniyan, Abisola ; Metcalf, Kevin J. ; Werb, Zena
  • Subjects: Review
  • Is Part Of: Nature communications, 2020-10, Vol.11 (1), p.1-19, Article 5120
  • Description: Abstract Tissues are dynamically shaped by bidirectional communication between resident cells and the extracellular matrix (ECM) through cell-matrix interactions and ECM remodelling. Tumours leverage ECM remodelling to create a microenvironment that promotes tumourigenesis and metastasis. In this review, we focus on how tumour and tumour-associated stromal cells deposit, biochemically and biophysically modify, and degrade tumour-associated ECM. These tumour-driven changes support tumour growth, increase migration of tumour cells, and remodel the ECM in distant organs to allow for metastatic progression. A better understanding of the underlying mechanisms of tumourigenic ECM remodelling is crucial for developing therapeutic treatments for patients.
  • Publisher: London: Nature Publishing Group UK
  • Language: English
  • Identifier: ISSN: 2041-1723
    EISSN: 2041-1723
    DOI: 10.1038/s41467-020-18794-x
    PMID: 33037194
  • Source: PubMed Central
    ProQuest Central
    DOAJ Directory of Open Access Journals
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